Empiric recurrence risks in common and uncommon congenital heart lesions

Nora, J.J.; McGill, C.W.; McNamara, D.G.

Teratology 3(4): 325-330


ISSN/ISBN: 0040-3709
PMID: 5538414
DOI: 10.1002/tera.1420030408
Accession: 026555564

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Empiric recurrence risks in sibs for the eight most common and four uncommon congenital heart lesions have been obtained from a study of 1405 patients with congenital cardiovascular malformations. Risks to offspring of parents with any of four common congenital heart diseases were determined in a study of 210 adults who had congenital heart defects and who had reproduced. The recurrence risks are presented and are found to approximate the prediction of the multifactorial inheritance hypothesis.