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Involvement of thiol enzymes in the lysosomal breakdown of native and denatured proteins

Huisman, W.; Bouma, J.M.; Gruber, M.

Biochimica et Biophysica Acta 297(1): 98-109

1973

ISSN/ISBN: 0006-3002
PMID: 4348323
DOI: 10.1016/0304-4165(73)90053-6
Accession: 026854840
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We have investigated the effect of thiols on the breakdown of some proteins by extracts from highly purified Triton WR-1339-filled rat liver lysosomes at pH 5 and 38°C.

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Related References

Bernheim, Frederick; Neurath, Hans; Erickson, J.0. 1942: The denaturation of proteins and its apparent reversal. IV. Enzymatic hydrolysis of native, denatured and apparently reversibly denatured proteins Journal of Biological Chemistry 144(1): 259-264
Ozimek, L.; Fengler, A.; Szpacenko, A.; Wolfe, F. 1991: Kinetics and efficiency of hydrolysis of native and denatured whey proteins by pancreatic enzymes in both batch and ultrafiltration membrane bioreactor systems Journal of Dairy Science 74(Suppl 1): 99
Katunuma, N.; Kominami, E. 1985: Lysosomal sequestration of cytosolic enzymes and lysosomal thiol cathepsins Advances in Enzyme Regulation 23: 159-168
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Reitman, M.L.; Kornfeld, S. 1981: Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes Journal of Biological Chemistry 256(23): 11977-11980
Ohshita, T. 2000: Native and acid-denatured L-lactate dehydrogenase are different in the lysosomal proteinases involving in their overall degradation Bioscience Biotechnology and Biochemistry 64(8): 1764-1766
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