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Leukocyte migration in agarose a study on multiple sclerosis evidence for qualitatively different responses to intact encephalitogenic protein and to peptides derived from it

HÅKA.B.RGSTRAND.B.NG.K.LLÉN.O.L.N.LSSON

Allergy 30(2-3): 150-166

1975


ISSN/ISBN: 0105-4538
DOI: 10.1111/j.1398-9995.1975.tb01338.x
Accession: 026893177

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The effect of low concentrations of bovine encephalitogenic protein on the migration of human peripheral leukocytes in agarose was studied. A concentration of 0.3 mug/ml of the protein stimulated the migration of cells from many donors, including some healthy subjects. An indirect technique suggested that the migration enhancement is due to the production of soluble factor, possibly corresponding to the leukocyte migration enhancement factor described by others.

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