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Leukocyte migration in agarose a study on multiple sclerosis evidence for qualitatively different responses to intact encephalitogenic protein and to peptides derived from it

HÃ…KA.B.RGSTRAND.B.NG.K.„LLÉN.O.L.N.LSSON

Allergy 30(2-3): 150-166

1975

ISSN/ISBN: 0105-4538
DOI: 10.1111/j.1398-9995.1975.tb01338.x
Accession: 026893177
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The effect of low concentrations of bovine encephalitogenic protein on the migration of human peripheral leukocytes in agarose was studied. A concentration of 0.3 mug/ml of the protein stimulated the migration of cells from many donors, including some healthy subjects. An indirect technique suggested that the migration enhancement is due to the production of soluble factor, possibly corresponding to the leukocyte migration enhancement factor described by others.

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Related References

Bergstrand, H.; Källén, B.; Nilsson, O. 1974: Effect of basic encephalitogenic protein and some peptides derived from it on the migration in agarose gel of leukocytes from patients with multiple sclerosis, other neurological diseases, or carcinoma Acta Neurologica Scandinavica 50(2): 227-247
Clanet, M.; Kuhlein, E.; Rascol, A.; Abbal, M.; Ohayon, E. 1979: Delayed hypersensitivity to human encephalitogenic protein as assayed by agarose leucocyte migration in multiple sclerosis patients Journal of the Neurological Sciences 42(2): 203-213
Källén, B.; Nilsson, O.; Thelin, C. 1977: Effect of encephalitogenic protein on migration in agarose of leukocytes from patients with multiple sclerosis. A longitudinal study of patients with relapsing multiple sclerosis or with cerebral infarction Acta Neurologica Scandinavica 55(1): 47-56
Källen, B.; Nilsson, O.; Thelin, C. 1977: Effect of encephalitogenic protein on migration in agarose of leukoytes from patients with multiple sclerosis. a longitudinal study of patients with relapsing multiple sclerosis or with cerebral infarction Acta Neurologica Scandinavica 55(1): 47-56
Kam-Hansen, S.; Kristensson, K.; Link, H. 1979: Observations on the effect of injection of lymphocytes from multiple sclerosis and Guillain-Barr syndrome in the rabbit eye model Journal of the Neurological Sciences 42(2): 283-289
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