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Mucosal protection during irradiation of exteriorized rat ileum. Effect of hypoxia induced by starch microspheres

Mucosal protection during irradiation of exteriorized rat ileum. Effect of hypoxia induced by starch microspheres

Acta Radiologica: Oncology Radiation Physics Biology 17(6): 485-496

Transient hypoxia induced by intra-arterial injection of degradable starch microspheres was used for protection of exteriorized segments of the rat ileum. Microscopic evaluation of the injury to the mucosa gave a dose modification factor of 0.44 +/- 0.04, which corresponds to an oxygen enhancement ratio of 2.30. A similar factor was also found from measurements of the mucosal weight. No significant development of mucosal oedema could be demonstrated, neither in protected nor in non-protected segments.

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Accession: 026999022

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PMID: 735853

DOI: 10.3109/02841867809128179

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