Section 28
Chapter 27,244

Purification, characterization and comparison of immunological properties of monkey chorionic somatomammotropin with human and monkey growth hormone, human chorionic somatomammotropin and ovine prolactin

Vinik, A.I.; Kaplan, S.L.; Grumbach, M.M.

Endocrinology 92(4): 1051-1064


ISSN/ISBN: 0013-7227
PMID: 4631305
DOI: 10.1210/endo-92-4-1051
Accession: 027243980

Download citation:  

An analysis of the constituents of the plasma membrane of a methylcholanthrene-induced sarcoma (the MC1 tumour) in a hooded rat revealed four tumour-associated macromolecules. Two of these were antigenic in the syngeneic host, one was unique to the MC1 tumour and could not be detected in embryo tissue and has the properties to be expected from the well established tumour-specific transplantation-type antigen while the other, referred to as OEA I, was present in all rat sarcomata tested as well as in early embryos. Two other embryonic components were detected in the sarcoma but these were not immunogenic in the rat. The properties of these tumour-associated "antigens" in the membrane of rat sarcomata are summarized below: [Table: see text]

Full Text Article emailed within 0-6 h: $19.90