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Studies on the syntheses of n hetero cyclic compounds part 18 syntheses of di substituted amino 2 phenyl pyrimido pyrimidine derivatives


, : Studies on the syntheses of n hetero cyclic compounds part 18 syntheses of di substituted amino 2 phenyl pyrimido pyrimidine derivatives. Journal of Takeda Research Laboratories 32(3): 251-258



Accession: 027487284

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Related references

Yurugi S.; Itoh K.; Miyake A.; Omura K., 1973: Studies on the syntheses of n hetero cyclic compounds part 19 synthesis of 4 alkyl 5 8 di substituted amino 2 phenyl 3 4 di hydro pyrimido 4 5 d pyridazine. Yakugaku Zasshi 93(8): 1043-1051

Kametani, T.; Kigasawa, K.; Hiragi, M.; Wagatsuma, N.; Kohagizawa, T.; Inoue, H.; Nakamura, T., 1981: Synthesis of analgesics 54. syntheses of 3 substituted phenyl 4 oxazolidinone and 3 substituted phenyl 3 4 5 6 tetra hydro 2h 1 3 oxazin 4 one derivatives as analgesics studies on the syntheses of hetero cyclic compounds 1928. 3-(4-Methoxyphenyl)-4-oxazolidinone (IIa) had analgesic activity as potent as aminopyrine and very low toxicity. To obtain more excellent analgesics, 3-(substituted phenyl)-4-oxazolidinones related to (IIa) and 3-(substituted phenyl)-3,4,5,6-tetra...

Uryu T., 1973: Syntheses of analgesics part 532 reactions of 2 3 substituted phenyl cyclo hexanone with ethyl alpha halo acetate studies on the syntheses of hetero cyclic compounds part 82. Yakugaku Zasshi: 1162-1164

Kametani, T.; Kigasawa, K.; Hiiragi, M.; Ishimaru, H.; Wagatsuma, N.; Kohagizawa, T.; Nakamura, T., 1980: Syntheses of analgesics 52. synthesis of 4a 3 substituted phenyl 1 2 di substituted deca hydro cinnoline derivatives syntheses of hetero cyclic compounds 843. A series of decahydrocinnoline derivatives [4a-(3-benzyloxyphenyl)-2-cyclopropylmethyldecahydrocinnoline, 4a-(3-hydroxyphenyl)-2-methyl-(cyclopropylmethyl)decahydrocinnoline, 2,1-acetyl-4a-(3-benzyloxyphenyl)decahydrocinnoline, 2,1-acetyl-4a-(3-hy...

Kametani, T.; Kigasawa, K.; Hiiragi, M.; Wagatsuma, N.; Kohagizawa, T.; Uryu, T.; Nakamura, T., 1982: Syntheses of analgesics 55. synthesis of 4a 3 substituted phenyl 1 2 di substituted deca hydro cinnoline derivatives 2. syntheses of hetero cyclic compounds 955. Novel decahydrocinnoline derivatives [compounds with both agonist and antagonist properties] were synthesized as analgesics. To prepare N-2-propenyl derivatives, the reduction of N-acryloyl compounds with various reducing agents (LiAlH4, NaBH4 and...

Okui K.; Ito K.; Koizumi M.; Fukumoto K.; Kametani T., 1972: Studies on the syntheses of hetero cyclic compounds 491 pyrimidine derivatives part 5 abnormal condensation products of 4 amino 6 chloro 2 methoxy pyrimidine with p nitrobenzenesulfonyl chloride. Journal of Heterocyclic Chemistry 9(6): 1283-1288

Kametani, T.; Kigasawa, K.; Hiiragi, M.; Ishimaru, H.; Nakamura, T.; Shirayama, K., 1980: Syntheses of analgesics 53. synthesis of 3 4 substituted phenyl 2 oxo butanamide derivatives syntheses of hetero cyclic compounds 845. Derivatives of 3-[4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)phenyl]-2-oxobutanamide, exhibiting potent antiinflammatory and analgesic activity, were obtained from 3-(4-aminophenyl)-2-oxo-butanamide (2) and 3-[4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)phen...

Yurugi S.; Fushimi T.; Hieda M., 1972: Studies on the syntheses of n hetero cyclic compounds part 9 on the reduction of 2 aryl 5 8 di substituted pyrimido 4 5 d pyridazine. Yakugaku Zasshi 92(11): 1316-1321

Kametani, T.; Kigasawa, K.; Hiiragi, M.; Wakisaka, K.; Kusama, O.; Sugi, H.; Kawasaki, K., 1977: Synthetic studies on chemo therapeutics part 2 synthesis of phenyl substituted 1 4 di hydro 4 oxo nicotinic acid derivatives studies on the syntheses of hetero cyclic compounds part 704. The thermal cyclization of the aminomethylenemalonates gave the 4-hydroxynicotinates (9), ethylation of which yielded N-ethylated (11) and O-ethylated products (12). Hydrolysis of 9, 11 and 12 led to the desired nicotinic acids.

Imai, K.; Ishida, T.; Horiguchi, H.; Ozasa, T.; Ohono, M.; Kawahara, S.; Murakami, M., 1976: Studies on the syntheses of sulfur containing pyrimido 5 4 d pyrimidine derivatives part 1 syntheses of pyrimido 5 4 d pyrimidine derivatives possessing methylsulfonyl or sulfonamide group at 2 position. Thirty-one kinds of pyrimido[5,4-d]pyrimidine derivatives possessing methylsulfonyl or sulfonamide group at 2-position were prepared by the reaction of 4,8-disubstituted 6-chloro-2-methylsulfonylpyrimido[5,4-d]pyrimidine or 4,8-disubstituted 6-chl...