Section 28
Chapter 27,614

The effect of sulfhydryl blockade on insulin action and glucose transport in isolated adipose tissue cells

Carter, J.R.; Martin, D.B.

Biochimica et Biophysica Acta 177(3): 521-526


ISSN/ISBN: 0006-3002
PMID: 5787246
DOI: 10.1016/0304-4165(69)90314-6
Accession: 027613475

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The effects of sulfhydryl blockade on glucose metabolism have been investigated using isolated adipose tissue cells from the rat and the specific sulfhydryl binding agent, N-ethylmaleimide. According to the conditions of the experiment, there can be (1) an insulin-like effect, (2) inhibition of insulin-stimulated glucose metabolism, and (3) inhibition of basal glucose metabolism. At least the first two effects appear to occur at the level of membrane transport.

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