The effect of sulfhydryl blockade on insulin action and glucose transport in isolated adipose tissue cells
Carter, J.R.; Martin, D.B.
Biochimica et Biophysica Acta 177(3): 521-526
1969
ISSN/ISBN: 0006-3002 PMID: 5787246 DOI: 10.1016/0304-4165(69)90314-6
Accession: 027613475
The effects of sulfhydryl blockade on glucose metabolism have been investigated using isolated adipose tissue cells from the rat and the specific sulfhydryl binding agent, N-ethylmaleimide. According to the conditions of the experiment, there can be (1) an insulin-like effect, (2) inhibition of insulin-stimulated glucose metabolism, and (3) inhibition of basal glucose metabolism. At least the first two effects appear to occur at the level of membrane transport.