Section 29
Chapter 28,402

Growth hormone release following administration of growth hormone releasing factor to growth hormone deficient and normal males

Culler, F.L.; Jones, K.L.

Pediatric Research 18(4 Part 2): 166A


ISSN/ISBN: 0031-3998
DOI: 10.1203/00006450-198404001-00440
Accession: 028401259

We have studied 4 males with idiopathic growth hormone (h GH) deficiency and 8 normal adult males comparing their responses to a 100 μg bolus infusion of the 44 amino acid synthetic growth hormone releasing factor (GRF-44). Responses were compared for changes in h GH, prolactin (PRL), insulin (I), glucagon (G) and glucose (Glu) concentration over a 2-hour period after injection of GRF-44. h Gh deficiency was initially documented using standard testing procedures. No patient had received h Gh replacement for at least one month prior to testing. The h Gh deficient patients had a significant (p 7 ng/ml) following Grf stimulation. The mean increase of the h Gh deficient group, however, was only 22% of the mean increase of the group of normal male controls. This confirms that patients with idiopathic h Gh deficiency may have h Gh release, though it is subnormal, following single bolus GRF-44 testing.

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