+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

HLA and genetics of IDDM. Holism vs. reductionism?



HLA and genetics of IDDM. Holism vs. reductionism?



Diabetes 37(8): 1005-1008



Analysis of HLA-associated susceptibility to insulin-dependent diabetes mellitus (IDDM) has largely focused on identifying the susceptibility gene. Adherents of a countertrend have long suggested the importance of analysis of HLA haplotypes (combinations of alleles on 1 chromosome) rather than individual genes. Accumulating data suggest that the relationship between IDDM susceptibility and HLA is much more complex than a single susceptibility gene. Consideration of this question should include the possibilities that 1) more than one HLA gene is involved in determining susceptibility or resistance; 2) different alleles of the same gene may be associated with different pathogenetic mechanisms; and 3) different susceptibility-associated haplotypes, even if they share an allele at an IDDM-relevant locus, may behave differently in IDDM. A better understanding of the genetics, and perhaps the pathogenesis, of IDDM may be obtained by following up the clues offered by analysis of the association of HLA haplotypes (rather than individual alleles) with one another, with clinical features of IDDM, and with possible non-HLA-linked susceptibility factors.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 028437193

Download citation: RISBibTeXText

PMID: 3292321

DOI: 10.2337/diab.37.8.1005


Related references

Holidays, ozone and skin cancer. Skin cancer in bristol--a comparison of theory with observation. Archives of Dermatological Research 274(1-2): 47-56, 1982

Reductionism and explanation in cell biology. Novartis Foundation Symposium 213: 93, 1998

Hole states in GaAs/AlAs double-barrier structures and multiple quantum wells. Semiconductor Science and Technology 9(3): 310-319, 1994

Reductional anomalies of the limbs. Larc Medical 2(11): 968-977, 1982

Systems theory, psychiatry, and school phobia. American Journal of Psychiatry 127(1): 25-32, 1970

Holism and reduction in sociobiology: lessons from the ants and human culture. Biology and Philosophy 64: 401-412, 1991

Holism and reductionism in ecology: hypotheses, scale and systems models. Oikos 532: 267-269, 1988

Holidays for the bereaved as a form of therapy. Bereavement Care 7(1): 5-5, 1988

Evolution ‘on purpose’ how behaviour has shaped the evolutionary process. Biological Journal of the Linnean Society 112(2): 242-260, 2014

Integrating high-throughput pyrosequencing and quantitative real-time PCR to analyze complex microbial communities. Methods in Molecular Biology 733: 107-128, 2011

Reduction rhinoplasty and nasal patency: Change in the cross-sectional area of the nose evaluated by acoustic rhinometry: Grymer LF. Laryngoscope 105:429, 1995. Journal of Oral and Maxillofacial Surgery 53(10): 1230-0, 1995

Chance at the heart of the cell. Progress in Biophysics and Molecular Biology 110(1): 1-4, 2012

Complexity and the reconnection of interdisciplinary knowledge: contribution of Edgar Morin's thoughts. Revista Brasileira de Enfermagem 65(4): 561-565, 2012

Reductionism and holism in biology. Symposium of the British Society for Developmental Biology 8: 407-433, 1986

Evolving from reactive to proactive medicine: community lead (Pb) and clinical disparities in pre- and post-Katrina New Orleans. International Journal of Environmental Research and Public Health 11(7): 7482-7491, 2014