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Immunocytochemically demonstrable icosapeptide fragment of the pancreatic polypeptide precursor presence in rectal but absence from pancreatic endocrine tumors containing pancreatic polypeptide immunoreactive cells


, : Immunocytochemically demonstrable icosapeptide fragment of the pancreatic polypeptide precursor presence in rectal but absence from pancreatic endocrine tumors containing pancreatic polypeptide immunoreactive cells. Digestive Diseases & Sciences 29(8 SUPPL): 85S



Accession: 028480850

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Related references

Bottcher G.; Sundler F.; Hakanson R.; Schwarz T.W., 1984: Immunocytochemical localization of the icosapeptide fragment of the pancreatic polypeptide precursor a marker for true pancreatic polypeptide cells?. Digestive Diseases & Sciences 29(8 SUPPL): 13S

Schwartz, T.W.; Hansen, H.F.; Håkanson, R.; Sundler, F.; Tager, H.S., 1984: Human pancreatic icosapeptide: isolation, sequence, and immunocytochemical localization of the COOH-terminal fragment of the pancreatic polypeptide precursor. In dogs, the COOH-terminal part of the pancreatic polypeptide precursor gives rise to a stable icosapeptide product against which an antiserum has been raised. By immunohistochemistry, icosapeptide immunoreactivity was localized in human pancrease...

Boel, E.; Schwartz, T.W.; Norris, K.E.; Fiil, N.P., 1984: A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide. A cDNA for the hormone, human pancreatic polypeptide (PP), was isolated by oligodeoxynucleotide screening from a cDNA library constructed from normal human pancreatic mRNA. The primary structure of the precursor protein as deduced from the cDNA se...

Schwartz, T.W., 1987: Cellular peptide processing after a single arginyl residue. Studies on the common precursor for pancreatic polypeptide and pancreatic icosapeptide. The processing of the common precursor for pancreatic polypeptide and pancreatic icosapeptide was studied in primary cultures of endocrine cells isolated from the duodenal part of the canine pancreas. Biosynthetically labeled peptides were charact...

Friesen, S.R.; Tomita, T.; Kimmel, J.R., 1983: Pancreatic polypeptide update: its roles in detection of the trait for multiple endocrine adenopathy syndrome, type I and pancreatic polypeptide-secreting tumors. Circulating human pancreatic polypeptide (hPP) concentrations in the plasma of 61 patients were determined by radioimmunoassay and compared with concentrations in normal age-matched subjects to assess the role of plasma hPP in diagnosis and detect...

Rawdon, B.B.; Andrew, A., 1979: An immunocytochemical study of the distribution of pancreatic endocrine cells in chicks, with special reference to the relationship between pancreatic polypeptide and somatostatin-immunoreactive cells. Araldite sections of formalin-fixed pancreas from chicks at hatching were treated by an indirect immuno-enzyme technique to reveal cells containing APP, somatostatin, glucagon and insulin. APP cells were found scattered in the exocrine parenchyma....

Larsson, L.I.; Schwartz, T.; Lundqvist, G.; Chance, R.E.; Sundler, F.; Rehfeld, J.F.; Grimelius, L.; Fahrenkrug, J.; Schaffalitzky de Muckadell, O.; Moon, N., 1976: Occurrence of human pancreatic polypeptide in pancreatic endocrine tumors. Possible implication in the watery diarrhea syndrome. Eighteen endocrine pancreatic tumors were examined for the occurrence of cells producing insulin, glucagon, gastrin, human pancreatic polypeptide (HPP), and vasoactive intestinal polypeptide (VIP) and for A1 cells. More than half of the tumors wer...

Adrian, T.E.; Uttenthal, L.O.; Williams, S.J.; Bloom, S.R., 1986: Secretion of pancreatic polypeptide in patients with pancreatic endocrine tumors. Pancreatic polypeptide is often secreted by pancreatic endocrine tumors and is considered a marker for such tumors. To investigate the diagnostic value of this marker, we studied 323 patients with proved pancreatic endocrine tumors. We found plasm...

Panzuto, F.; Severi, C.; Cannizzaro, R.; Falconi, M.; Angeletti, S.; Pasquali, A.; Corleto, V.D.; Annibale, B.; Buonadonna, A.; Pederzoli, P.; Delle Fave, G., 2004: Utility of combined use of plasma levels of chromogranin A and pancreatic polypeptide in the diagnosis of gastrointestinal and pancreatic endocrine tumors. Background: Chromogranin A (CgA) is considered the most accurate marker in the diagnosis of gastro-entero-pancreatic (GEP) endocrine tumors. Pancreatic polypeptide (PP) has also been proposed to play this role, but then not used due to its low sen...

Rogers, W.A.; O'Dorisio, T.M.; Johnson, S.E.; Cataland, S.; Stradley, R.P.; Sherding, R.G., 1983: Postprandial release of gastric inhibitory polypeptide (GIP) and pancreatic polypeptide in dogs with pancreatic acinar atrophy. Correction of blunted GIP response by addition of pancreatic enzymes to a meal. To evaluate the enteropancreatic hormone axis in dogs with pancreatic acinar atrophy, the release of gastric inhibitory polypeptide and pancreatic polypeptide in response to a standard meal and a meal containing pancreatic enzymes was estimated in...