+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Interactions of drugs and electroshock treatment on cerebral monoaminergic systems

Interactions of drugs and electroshock treatment on cerebral monoaminergic systems

Annals of the new York Academy of Sciences 462: 147-162

The interaction of EST and drugs on the CSF levels of several monoamine metabolites was studied with four drugs that have been used in the treatment of psychiatric disorders, namely, lithium, carbamazepine, imipramine, and haloperidol. EST-drug interactions were observed with each of these drugs on one or more monoaminergic systems. All interactions were antagonistic in nature. Changes in the CSF levels of monoamine metabolites did not always reflect corresponding changes in the monoamine turnover; the increase in 5HIAA seen after chronic Li was due to slower removal of this metabolite from the CSF. However, the changes in the CSF levels of DA and 5HT metabolites following chronic HLDL reflected changes in the turnover of the parent amine in the brain. The effects of both HLDL and EST on DA metabolism in the intact brain could be related to alterations by these treatments of the responsiveness of DA presynaptic receptors. Similarly, the effect of HLDL on 5HT turnover and the antagonistic interaction of EST on this HLDL-induced effect were associated with changes in 3H-IMI binding sites that label the 5HT transporter in serotonergic presynaptic terminals. The results are discussed with the aid of a model that depicts possible relationships between pre- and postsynaptic variables and their influence on each other. According to this model an increase in the neurotransmitter turnover is associated with "down regulation" of both pre- and postsynaptic receptors whereas a decrease in turnover is associated with receptor "up regulation." However, "up regulation" of receptors is not necessarily associated with augmented postsynaptic response. Analysis of the model variables by the "binding equation" which obeys the Clark occupancy principle revealed that receptor "up regulation" which is associated with decreased turnover may result in either an augmented or a depressed postsynaptic response (related to the number of occupied receptors). The direction of the response depends on the ratio between the rate of receptor "up regulation" and the rate of decrease in neurotransmitter turnover.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 028560119

Download citation: RISBibTeXText

PMID: 2423001

DOI: 10.1111/j.1749-6632.1986.tb51249.x

Related references

Pharmacological modulation of central monoaminergic systems and influence on the anticonvulsant effectiveness of standard antiepileptics in maximal electroshock seizure. Biomedica Biochimica Acta 47(7): 631-645, 1988

Right to refuse electroshock treatment--involuntary electroshock treatment on court order, when--hearing--emergency electroshock treatment, when. Missouri Statutes Annotated 1929, Including Laws of the 56th General Assembly, 1931, Together With Annotations From the Cases Construing Thos.. Section 202.213: Unknown-Unknown, 1979

Interactions between monoaminergic neurons projecting to the cerebral cortex. L'Union Medicale du Canada 114(12): 964, 1985

Monoaminergic systems in the action of antidepressant and anxiolytic drugs. Racagni, G And E Smeraldi (Ed ) Anxious Depression: Assessment And Treatment; Workshop, Milan, Italy, September 22-23, 1986 Xxi+233p Raven Press: New York, New York, Usa Illus 121-126, 1987

Interactions between central monoaminergic systems: dopamine-serotonin. Journal of Neurology Neurosurgery and Psychiatry 42(12): 1159-1162, 1979

Two noradrenergic systems in the brain and their interactions with other monoaminergic neurons. Polish Journal of Pharmacology and Pharmacy 31(4): 425-436, 1979

The effects of amphetamine-like designer drugs on monoaminergic systems in rat brain. Nida Research Monograph 76: 316-321, 1987

Interactions between ACE inhibitors and classical antiepileptic drugs in the mouse maximal electroshock seizures. Pharmacology Biochemistry and Behavior 100(1): 152-156, 2011

Electrophysiologic manifestations of the effect of monoaminergic systems on the cerebral cortex. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 72(8): 1039-1047, 1986

Electrophysiological manifestations of the monoaminergic systems' effects on the cerebral cortex. Neuroscience and Behavioral Physiology 17(2): 152-160, 1987

Effect of drugs acting on monoaminergic and cholinergic systems on the quantified EEG of rats. Neuropsychobiology 21(4): 205-215, 1989

Interactions of the glycine antagonist, MDL 103,371 with monoaminergic systems Evidence for antipsychotic-like activity. Society for Neuroscience Abstracts 22(1-3): 1535, 1996

5-6-Dihydroxytryptamine as a tool for studying sleep mechanisms and interactions between monoaminergic systems. Annals of the new York Academy of Sciences 305: 576-589, 1978

Interactions between angiotensin AT1 receptor antagonists and second-generation antiepileptic drugs in the test of maximal electroshock. Fundamental and Clinical Pharmacology 28(3): 277-283, 2014

Interactions between angiotensin AT1 receptor antagonists and second-generation antiepileptic drugs in the test of maximal electroshock. 2013