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Interactive effects of pcdds and pcdfs occurring in human mothers milk



Interactive effects of pcdds and pcdfs occurring in human mothers milk



Chemosphere 16(8-9): 1701-1706



A mixture of 14 PCDDs and PCDFs was administered to male Sprague-Dawley rats in a single oral dose. After 4 weeks the animals were sacrificed, and body weight gain, relative liver and thymus weights, cytochrome P-448/450, AHH, UDPGT as well as hepatic, renal and serum vitamin A, were determined. The results were compared to positive control groups given only TCDD. Additive effects were observed with regard to parameters such as thymus involution, cytochrome P-448, renal vitamin A, AHH, and UDPGT. No additive effects were observed with respect to effects on hepatic vitamin A reduction thus indicating that this response is mediated by different mechanism.

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Accession: 028560846

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DOI: 10.1016/0045-6535(87)90153-6


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