Residues at the acetylcholine binding site and at a noncompetitive inhibitor binding site may be contained in a single functional domain of the receptor alpha subunit
Dipaola, M.; Kao, P.N.; Karlin, A.
Society for Neuroscience Abstracts 12(2): 961
1986
ISSN/ISBN: 0190-5295
Accession: 029084913
PDF emailed within 1 workday: $29.90
Related References
Czajkowski, C.; Karlin, A. 1995: Structure of the nicotinic receptor acetylcholine-binding site. Identification of acidic residues in the delta subunit within 0.9 nm of the 5 alpha subunit-binding Journal of Biological Chemistry 270(7): 3160-3164Donnelly-Roberts, D.L.; Lentz, T.L. 1991: Binding sites for alpha-bungarotoxin and the noncompetitive inhibitor phencyclidine on a synthetic peptide comprising residues 172-227 of the alpha-subunit of the nicotinic acetylcholine receptor Biochemistry 30(30): 7484-7491
Czajkowski, C.; Karlin, A. 1991: Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide Journal of Biological Chemistry 266(33): 22603-22612
Pedersen, S.E.; Sharp, S.D.; Liu, W.S.; Cohen, J.B. 1992: Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262 Journal of Biological Chemistry 267(15): 10489-10499
Pedersen, S.E.; Papineni, R.V. 1995: Interaction of d-tubocurarine analogs with the Torpedo nicotinic acetylcholine receptor. Methylation and stereoisomerization affect site-selective competitive binding and binding to the noncompetitive site Journal of Biological Chemistry 270(52): 31141-31150
Tzartos, S.J.; Remoundos, M.S. 1990: Fine localization of the major alpha-bungarotoxin binding site to residues alpha 189-195 of the Torpedo acetylcholine receptor. Residues 189, 190, and 195 are indispensable for binding Journal of Biological Chemistry 265(35): 21462-21467
Donnellyroberts, D.L.; Lentz, T.L. 1991: Binding sites for α-bungarotoxin and the noncompetitive inhibitor phencyclidine on a synthetic peptide comprising residues 172-277 of the α-subunit of the nicotinic acetylcholine receptor Biochemistry (Easton) 30(30): 7484-7491
Donnelly Roberts, D.L.; Lentz, T.L. 1991: Binding sites for a-bungarotoxin and the noncompetitive inhibitor phencyclidine on a synthetic peptide comprising residues 172-227 of the a-subunit of the nicotinic acetylcholine receptor Biochemistry (American Chemical Society) 30: 84-91
DiPaola, M.; Kao, P.N.; Karlin, A. 1990: Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor Journal of Biological Chemistry 265(19): 11017-11029
Czajkowski, C.; Karlin, A. 1991: Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the d subunit within 0.9 nm of the a subunit binding site disulfide Journal of Biological Chemistry 266: 603-612
Czajkowski, C.; Karlin, A. 1991: Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor : a negatively charged region of the δ subunit within 0.9 nm of the α subunit binding site disulfide Journal of Biological Chemistry 266(33): 22603-22612
Johnson, D.A.; Ayres, S. 1996: Quinacrine noncompetitive inhibitor binding site localized on the Torpedo acetylcholine receptor in the open state Biochemistry 35(20): 6330-6336
Wang, Z.Z.; Hardy, S.F.; Hall, Z.W. 1996: Membrane tethering enables an extracellular domain of the acetylcholine receptor alpha subunit to form a heterodimeric ligand-binding site Journal of Cell Biology 135(3): 809-817
Gotti, C.; Mazzola, G.; Longhi, R.; Fornasari, D.; Clementi, F. 1987: The binding site for alpha-bungarotoxin resides in the sequence 188-201 of the alpha-subunit of acetylcholine receptor: structure, conformation and binding characteristics of peptide [Lys] 188-201 Neuroscience Letters 82(1): 113-119
Johnson, D.A.; Aryes, S. 1996: Localization of the quinacrine noncompetitive inhibitor binding site on the open-channel conformation of the Torpedo acetylcholine receptor Biophysical Journal 70(2 Part 2): A98