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Structure and toxicity of the alkaloids of russian comfrey symphytum uplandicum a medicinal herb and item of human diet


, : Structure and toxicity of the alkaloids of russian comfrey symphytum uplandicum a medicinal herb and item of human diet. Experientia (Basel) 36(4): 377-379



Accession: 029225468

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Related references

Culvenor, C.C.; Clarke, M.; Edgar, J.A.; Frahn, J.L.; Jago, M.V.; Peterson, J.E.; Smith, L.W., 1980: Structure and toxicity of the alkaloids of Russian comfrey (symphytum x uplandicum Nyman), a medicinal herb and item of human diet. Eight pyrrolizidine alkaloids of hepatotoxic type have been indentified in leaves of Symphytum X uplandicum. The combined alkaloids exhibit chronic hepatotoxicity in rats.

Culvenor, C.C.J.; Clarke, M.; Edgar, J.A.; Frahn, J.L.; Jago, M.V.; Peterson, J.E.; Smith, L.W., 1980: Structure and toxicity of the alkaloids of Russian comfrey (Symphytum X uplandicum Nyman), a medicinal herb and item of human diet. Eight pyrrolizidine alkaloids of hepatotoxic type have been indentified in leaves of Symphytum X uplandicum. The combined alkaloids exhibit chronic hepatotoxicity in rats.

Culvenor, C.C.J.; Edgar, J.A.; Frahn, J.L.; Smith, L.W., 1980: The alkaloids of Symphytum X uplandicum (Russian comfrey). Eight pyrrolizidine alkaloids were identified in the leaves of Symphytum X uplandicum. They were echimidine, symphytine, lycopsamine, intermedine and the 4 new alkaloids 7-acetyllycopsamine, 7-acetylintermedine, symlandine (7-angelyl-9-viridiflory...

Culvenor C.C.J.; Edgar J.A.; Frahn J.L.; Smith L.W., 1980: The alkaloids of symphytum uplandicum russian comfrey. Eight pyrrolizidine alkaloids were identified in the leaves of Symphytum .times. uplandicum Nyman [S. officinale .times. S. asperum] (Russian comfrey) [used as a medicinal herb]. They are echimidine, symphytine, lycopsamine, intermedine and 4 new...

Barna, M.; Kucera, A.; Hladíkova, M.; Kucera, M., 2012: Randomized double-blind study: wound-healing effects of a Symphytum herb extract cream (Symphytum×uplandicum Nyman) in children. The wound healing effects of the topically applied preparation Traumaplant® containing a concentrate (10% active ingredient) from the aerial parts of medicinal comfrey (Symphytum × uplandicum Nyman) were examined in a randomized, controlled, cli...

Barna, M.; Kucera, A.; Hladícova, M.; Kucera, M., 2007: Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study. Wound healing effects of a topically applied preparation (Traumaplant) containing a concentrate (10 % active ingredient) from the aerial parts of medicinal comfrey (Symphytum x uplandicum NYMAN: ) were examined in a randomized clinical double-blin...

Brown, A.W.; Stegelmeier, B.L.; Colegate, S.M.; Gardner, D.R.; Panter, K.E.; Knoppel, E.L.; Hall, J.O., 2015: The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey-derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus). Comfrey (Symphytum officinale), a commonly used herb, contains dehydropyrrolizidine alkaloids that, as a group of bioactive metabolites, are potentially hepatotoxic, pneumotoxic, genotoxic and carcinogenic. Consequently, regulatory agencies and in...

Cook, K.K.; White, K.D.; Rader, J.I., 2004: Use of pyrrolizidine alkaloid profiles to distinguish Symphytum officinale from S x uplandicum in comfrey products sold in the United States. In 2001, the FDA advised removal of comfrey products recommended for internal use from the U.S. market because they contain pyrrolizidine alkaloids (PAs). However, a number of comfrey products are still available in health food stores and via the...

Hart R.H.; Thompson A.J.IIi; Elgin J.H.Jr; Mcmurtrey J.E.IIi, 1981: Forage yield and quality of quaker comfrey symphytum uplandicum alfalfa medicago sativa and orchard grass dactylis glomerata. Quaker comfrey (S. .times. uplandicum Nym.) has been promoted for years as a high-yielding protein-rich forage crop. Although considerable research has been done in other countries, almost none has been reported from the USA. Field trials on a Cod...

Basler, A., 1972: Cytotaxonomic study of the genus Symphytum L. of the Boraginaceae family. studies on the predominantly north German plants of the species of Symphytum asperum Lepech., Symphytum officinale L., and Symphytum X uplandicum Nym