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Tissue distribution of tritium labeled actinomycin d adsorbed on poly butyl cyano acrylate nanoparticles

Kante, B.; Couvreur, P.; Lenaerts, V.; Guiot, P.; Roland, M.; Baudhuin, P.; Speiser, P.

International Journal of Pharmaceutics 7(1): 45-54, 1980

1981

ISSN/ISBN: 0378-5173
Accession: 029456336
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Suspensions of polybutylcyanoacrylate nanoparticles were characterized morphologically. The influence of the adsorption of [3H]actinomycin D on these particles upon the tissue distribution of the drug was studied in rats; 24 h after injection, adsorbed [3H]actinomycin D is 5.6-, 44- and 64-fold more concentrated than the free drug in muscle, spleen and liver, respectively. The urinary excretion of [3H]actinomycin D is diminished when the drug is bound to polybutylcyanoacrylate nanoparticles.

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