+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies



2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies



Bioorganic and Medicinal Chemistry Letters 18(2): 793-797



A set of regioisomeric 2-substituted pyridazin-3(2H)-ones containing a 3-oxo-3-phenylprop-1-en-1-yl fragment at either position 4, 5 or 6 and 2-substituted pyridazin-3(2H)-ones containing the same fragment both at positions 4 and 5 have been synthesized and evaluated as antiplatelet agents. The study allows the identification of a new highly potent platelet aggregation inhibitor (4c).

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 029572592

Download citation: RISBibTeXText

PMID: 18053717

DOI: 10.1016/j.bmcl.2007.11.034


Related references

Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones. Bioorganic and Medicinal Chemistry Letters 16(4): 1080-1083, 2006

Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors. Journal of Medicinal Chemistry 57(6): 2807-2812, 2014

Synthesis and biological evaluation of (E)-1-(substituted)-3-phenylprop-2-en-1-ones bearing rhodanines as potent anti-microbial agents. Journal of Enzyme Inhibition and Medicinal Chemistry 29(5): 647-653, 2014

Action of grignard reagents on 6-(α-styryl)pyridazin-3(2H)-ones; synthesis of some 4-Substituted 6-(α-Styryl)-pyridazin-3(2H)-ones. Advanced Synthesis & Catalysis 326(5): 799-803, 1984

Synthesis, crystal structure and antidiabetic activity of substituted (E)-3-(Benzo [d]thiazol-2-ylamino) phenylprop-2-en-1-one. European Journal of Medicinal Chemistry 59: 304-309, 2013

Synthesis of 3 phenoxybenzyl 1r trans 2 2 dimethyl 3 2 phenyl p substituted phenylprop 1 enylcyclopropanecarboxylates from dextro 3 carene. Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 24(2): 154-158, 1985

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists. Journal of Medicinal Chemistry 62(10): 5242-5248, 2019

Synthesis, antitubercular, antifungal and antibacterial activities of 6-substituted phenyl-2-(3'-substituted phenyl pyridazin-6'-yl)-2,3,4,5-tetrahydropyridazin-3-one. Acta Poloniae Pharmaceutica 65(3): 353-362, 2008

Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 24(21): 5093-5097, 2014

Potassium Hydroxide Impregnated Alumina (KOH-Alumina) as a Recyclable Catalyst for the Solvent-Free Multicomponent Synthesis of Highly Functionalized Substituted Pyridazines and/or Substituted Pyridazin-3(2H)-ones under Microwave Irradiation. Isrn Organic Chemistry 2011: 406427, 2011

Synthesis of Furo[2,3- d ]pyridazin-4(5 H )-one and Its N(5) -Substituted Derivatives. Helvetica Chimica Acta 97(11): 1487-1496, 2014

Synthesis of new serotonergic 2-substituted 4,6-diaryl pyridazin-3-ones. Arzneimittel-Forschung 45(9): 947-951, 1995

Substituted [(dihydroisoxazolyl)sulfonylmethyl]pyridazin-3(2H)-ones: Herbicidal inhibitors of VLCFA biosynthesis. Abstracts of Papers of the American Chemical Society 248, 2014

Synthesis and complete 1H, 13C and 15N NMR assignment of substituted isoxazolo[3,4-d]pyridazin-7(6H)-ones. Magnetic Resonance in Chemistry 43(3): 240-245, 2005

Synthesis of 4,5-functionalized-2-methyl-6-(substituted aryl)-3 (2H)-pyridazinones: a new group of potent platelet aggregation inhibitors. Farmaco 52(3): 173-178, 1997