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A Na:H exchanger subtype mediates volume regulation in bovine corneal epithelial cells



A Na:H exchanger subtype mediates volume regulation in bovine corneal epithelial cells



Advances in Experimental Medicine and Biology 350: 105-110



To identify a role for a Na:H (NHE) exchanger subtype in volume regulation in bovine corneal epithelium, we determined: 1. its sensitivity to inhibition by amiloride analogues 2. the effects of either Cl removal or hypertonicity on the intracellular pH. Our results suggest that volume regulatory responses elicited by stimulation of NHE-2 may help preserve epithelial barrier function in the face of increases in tear film osmolarity.

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Accession: 029592947

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PMID: 8030460


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