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A comparison of reactions in guinea pigs inoculated with a type C foot-and-mouth disease virus bovine strain adapted to guinea pigs, and with the same strain adapted to 24-40 days old mice



A comparison of reactions in guinea pigs inoculated with a type C foot-and-mouth disease virus bovine strain adapted to guinea pigs, and with the same strain adapted to 24-40 days old mice



Ann Inst Pasteur 104(4): 529-534



A type C foot-and-mouth disease virus bovine strain was adapted to guinea pigs (36 intradermal passages) and to 24-40 day old mice (60 intramuscular passages). In guinea pigs, the guinea pig-adapted strain retained its epitheliotropic character; the mouse-adapted strain was at the same time epitheliotropic and myotropic. Certain guinea pigs which did not present any pathological symptoms after the first inoculation were tested with an intradermal injection of the guinea pig-adapted virus: 16 of 78 animals receiving the guinea pig virus, and 73 of 96 receiving the mouse virus were immune.

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