EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

A histological and histochemical experimental analysis of the liver in the course of regeneration after hepatectomy accompanied by cholestasis and in the course of cholestasis alone



A histological and histochemical experimental analysis of the liver in the course of regeneration after hepatectomy accompanied by cholestasis and in the course of cholestasis alone



Arch De Vecchi Anat Patol Med Clin 36(2): 431-476



30 female albino rats were divided into three groups. Group I consisted of rats subjected to hepatectomy (70% of the parenchyma removed); in addition, their bile ducts were ligated at the same time. In group II, only the bile ducts were ligated. Group III consisted of controls. Liver regeneration was not inhibited by cholestasis and regenerating liver parenchyma (after hepatectomy) was less sensitive to the damage caused by cholestasis. Compared to rats with only a ligated bile duct, rats subjected to hepatectomy and cholestasis appeared to show an increase in liver RNA. In both experimental conditions, there was an increase in dephosphorylating activity and a decrease in succinic dehydrogenase levels. The latter effect occurs within a shorter period of time in rats of group I (cholestasis and hepatectomy) when compared to those of group II (cholestasis without hepatectomy).

(PDF emailed within 1 workday: $29.90)

Accession: 029660708

Download citation: RISBibTeXText



Related references

The effect of extrahepatic cholestasis on liver regeneration after partial hepatectomy in the rat. Liver 15(5): 242-246, 1995

Effect of cholestasis of the liver to be resected on liver regeneration after hepatectomy in rats. Dokkyo Journal of Medical Sciences 26(1): 111-121, March, 1999

Experimental cholestasis in albino rat. IV. Effect of cholestasis in normal liver and in steatosis. Archivio Italiano di Anatomia E Istologia Patologica 27(4): 325-337, 1954

Regenerative phenomena of the striated muscular tissue in the course of experimental cholestasis (inhibition of cholestasis on regeneration of the striated muscle fibers). Archivio "de Vecchi" Per L'anatomia Patologica E la Medicina Clinica 47(1): 169-182, 1966

Ultrastructural-morphometric analysis of liver biopsies in patients with intrahepatic cholestasis. I. Correlations between morphometry of bile canaliculi and so-called "marker enzymes of cholestasis". Virchows Archiv. A, Pathological Anatomy and Histology 367(1): 15-26, 1975

NR1H4 analysis in patients with progressive familial intrahepatic cholestasis, drug-induced cholestasis or intrahepatic cholestasis of pregnancy unrelated to ATP8B1, ABCB11 and ABCB4 mutations. Clinics and Research in Hepatology and Gastroenterology 36(6): 569-573, 2013

Ultrastructural morphometric analysis of liver biopsies in patients with intra hepatic cholestasis part 1 correlations between morphometry of bile canaliculi and so called marker enzymes of cholestasis. Virchows Archiv Abteilung A Pathologische Anatomie 367(1): 15-26, 1975

Experimental cholestasis of the rat caused by solitary doses of -naphthyl-isothiocyanate Histological and enzymehistochemical alterations in the liver. 1965

Influence of a new liver-protective agent on the regeneration of the liver after experimental hepatectomy. Histochemical research. Archivio Per le Scienze Mediche 114: 554-575, 1962

Symposion B: Experimental cholestasis--in vitro metabolism and in vivo metabolic clearance of hexobarbital in rats with ANIT-cholestasis. Verhandlungen der Deutschen Gesellschaft für Innere Medizin 82 Pt 1: 269-271, 1976

Late-Onset Drug-Induced Cholestasis in a Living-Related Liver Transplant Donor With Progressive Familial Intrahepatic Cholestasis. Experimental and Clinical Transplantation 13 Suppl 3: 107-109, 2016

Experimental cholestasis metabolism in vitro and metabolic clearance in vivo of hexo barbital in rats with alpha naphthyl iso thio cyanate cholestasis. Verhandlungen der Deutschen Gesellschaft fuer Innere Medizin 82(PART 1): 269-271, 1976

Cholestasis After Pediatric Liver Transplantation-Recurrence of a Progressive Familial Intrahepatic Cholestasis Phenotype as a Rare Differential Diagnosis: A Case Report. Transplantation Proceedings 49(7): 1628-1633, 2017

A multivariate analysis of factors predictive of parenteral nutrition-related cholestasis (TPN cholestasis) in VLBW infants. Journal of the Singapore Paediatric Society 32(3-4): 144-148, 1990

Enzymological and histological changes in experimental cholestasis. Deutsche Zeitschrift für Verdauungs- und Stoffwechselkrankheiten 27(3): 83-94, 1967