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Gaucher's disease;thirty-two years experience at Siriraj Hospital
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A history of the anal ducts and anal-duct carcinoma; report of a case


A history of the anal ducts and anal-duct carcinoma; report of a case



Cancer 8(5): 979-985



ISSN/ISBN: 0008-543X

PMID: 13261054

DOI: 10.1002/1097-0142(1955)8:5<979::aid-cncr2820080521>3.0.co;2-r

Anal ducts can be shown in most humans, especially in the posterior anal canal. Their orifices lie within the crypts and are lined by squamous epithelium which merges with transitional epithelium. The branching tubules are lined by columnar cells in 2 or 3 layers, and mucus secretion can be shown in from 10-35% of the glands. The glands have no known function. Five previously reported cases of anal duct carcinoma are considered acceptable by the authors. An asymptomatic mucoepidermoid carcinoma of anal duct origin was discovered when only 3-4 mm in greatest diameter, and cured by local excision, as proven at autopsy 17 months later. It is probable that transitional cell, basal cell, squamous cell, adeno-, or mucoepidermoid carcinomas can originate in anal ducts. Since all of these types can also develop in tissues immediately adjacent to anal ducts they must be discovered when quite small if one hopes to prove anal duct origin. Considerable variation of types of anal duct carcinoma is predicted because of the histological nature of the normal duct, and because these neoplasms are considered to be analagous to those of salivary duct origin, which are well known for their marked variation in microscopic appearance.

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Accession: 029661312

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