+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases polymerases

A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases polymerases

Nature Structural Biology 5(11): 959-964

ISSN/ISBN: 1072-8368

A novel class of DNA-binding domains has been established from at least sixteen recently identified DNA-binding proteins. The three-dimensional structure of one of these domains, Mrf-2, has been solved using NMR methods. This structure is significantly different from known DNA-binding domain structures. The mechanism of DNA recognition by this motif has been suggested based on conserved residues, surface electrostatic potentials and chemical shift changes. This new DNA-binding motif shares structural homology with T4 RNase H, E. coli endonuclease III and Bacillus subtilis DNA polymerase I. The structural homology suggests a mechanism for substrate recognition by these enzymes.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 029731542

Download citation: RISBibTeXText

Related references

A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases. Nature Structural Biology 5(11): 959-964, 1998

Disruption of Src homology 3-binding motif within non-structural protein 1 of influenza B virus unexpectedly enhances viral replication in human cells. Journal of General Virology 97(11): 2856-2867, 2016

MCM4 shares homology to a replication/DNA-binding domain in CTF and is contacted by pRb. Biochemical and Biophysical Research Communications 317(3): 779-786, 2004

TRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proceedings of the National Academy of Sciences of the United States of America 107(47): 20305-20310, 2010

The N-terminal domain of Staphylothermus marinus McrB shares structural homology with PUA-like RNA binding proteins. Journal of Structural Biology 211(3): 107572, 2020

The peptide-binding motif of HLA-DR8 shares important structural features with other type 1 diabetes-associated alleles. Genes and Immunity 12(7): 504-512, 2011

An immunoreactive 38-kilodalton protein of Ehrlichia canis shares structural homology and iron-binding capacity with the ferric ion-binding protein family. Infection and Immunity 73(1): 62-69, 2005

The archaeal RecJ-like proteins: nucleases and ex-nucleases with diverse roles in replication and repair. Emerging Topics in Life Sciences 2(4): 493-501, 2018

The essential Schizosaccharomyces pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces cerevisiae DNA43 (MCM10) gene. Current Genetics 34(3): 164-171, 1998

DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair. Genes and Development 12(16): 2598-2609, 1998

Extracellular alpha/beta-hydrolase from Paenibacillus species shares structural and functional homology to tobacco salicylic acid binding protein 2. Journal of Structural Biology 210(3): 107496, 2020

The novel human HUEL (C4orf1) protein shares homology with the DNA-binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner. International Journal of Biochemistry and Cell Biology 34(5): 487-504, 2002

The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif. Embo Journal 17(16): 4545-4558, 1998

The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair. Journal of Biological Chemistry 273(3): 1453-1461, 1998

HIV-1 Gag shares a signature motif with annexin (Anx7), which is required for virus replication. Proceedings of the National Academy of Sciences of the United States of America 96(6): 2704-2709, 1999