Absorption of nucleic acids in intact mammalian cells

Schell, P.L.

Z NATUR FORSCH 22b(5): 529-532


Accession: 029846707

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The experimental control of cell functions in animal cells by the action of RNA and DNA was described and interpreted as the effect of the penetration of nucleic acid. An attempt was made to determine whether the penetration of RNA into "viable" cells could be measured directly. It is shown that radio-actively labelled nucleic acids can penetrate into such cells. Control experiments excluded the possibility that the absorption of polymerized materials proceeds as a fragmentation and resynthesis and that instead of the postulated incorporation, an adsorption on the cell surface occurs.