EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Acute megakaryoblastic leukemia with massive myelofibrosis: complete remission and reversal of marrow fibrosis with allogeneic bone marrow transplantation as the only treatment



Acute megakaryoblastic leukemia with massive myelofibrosis: complete remission and reversal of marrow fibrosis with allogeneic bone marrow transplantation as the only treatment



Bone Marrow Transplantation 6(6): 449-452



We report results of allogeneic bone marrow transplantation in an 8-year-old boy with acute megakaryoblastic leukemia characterized by intense fibrosis together with 20% blast cells in the bone marrow, who was transplanted without preceding chemotherapy for remission induction. Conditioning comprised cytosine arabinoside, cyclophosphamide and total body irradiation. The donor was his HLA-identical sister. The patient is well with minor chronic graft-versus-host disease and normal hematologic values 670 days post-transplant.

(PDF emailed within 1 workday: $29.90)

Accession: 029891748

Download citation: RISBibTeXText

PMID: 2097015



Related references

Reversal of myelofibrosis is an important pre-transplant factor for bone marrow grafting--a successful case of allogeneic bone marrow transplantation for an acute megakaryoblastic leukemia. Japanese Journal of Clinical Hematology 35(2): 148-153, 1994

Reversal of marrow fibrosis in acute megakaryo blastic leukemia after remission induction and consolidation chemo therapy followed by bone marrow transplantation. British Journal of Haematology 53(3): 445-450, 1983

Prospective phase III study of autologous bone marrow transplantation nu short intensive chemotherapy nu allogeneic bone marrow transplantation during first complete remission of acute myelogenous leukemia Results of the EORTC-GIMEMA AML8A trial. Blood 82(10 SUPPL 1): 85A, 1993

Hla matched t cell depleted allogeneic bone marrow transplantation in the treatment of acute leukemia in 1st complete remission. Bone Marrow Transplantation 1(SUPPL 1): 91, 1986

Comparison of allogeneic and autologous bone marrow transplantation for treatment of acute myeloblastic leukemia in childhood in first complete remission. Blood 84(10 SUPPL 1): 725A, 1994

Comparison of allogeneic and autologous bone marrow transplantation for treatment of acute myelocytic leukemia in childhood in first complete remission. Annals of Hematology 68(2): A34, 1994

Allogeneic bone marrow transplantation versus chemotherapy in the treatment of childhood acute lymphoblastic leukemia in second complete remission. Bone Marrow Transplantation 4(6): 609-612, 1989

Allogeneic bone marrow transplantation is the treatment of choice in young patients with acute myeloid leukemia in first complete remission. Experimental Hematology (Charlottesville) 19(6): 571, 1991

Autologous or allogeneic bone marrow transplantation for acute myeloblastic leukemia in second complete remission. Importance of duration of first complete remission in final outcome. Bone Marrow Transplantation 17(6): 979-984, 1996

Is allogeneic bone marrow transplantation the best treatment for young adult patients with acute myeloid leukemia in first complete remission. The BGMT Group. Leukemia 6 Suppl 2: 124-126, 1992

CD6-depleted allogeneic bone marrow transplantation for acute leukemia in first complete remission. Blood 89(8): 3039-3047, 1997

Allogeneic bone marrow transplantation for acute lymphoblastic leukemia during first complete remission. Transplantation 43(3): 389-392, 1987

Evolution of allogeneic bone marrow transplantation in Europe Improved results for patients with acute leukemia in first remission For the Acute Leukemia Working Party of the European Group for Bone Marrow Transplantation. Blood 82(10 SUPPL 1): 291A, 1993

Acute lymphoblastic and nonlymphoblastic leukemia in 1st complete remission: consolidation treatment by intensive radio-chemotherapy followed by transplantation of HLA-A, B and Dr compatible allogeneic bone marrow. L'union Medicale du Canada 115(10): 699-702, 1986

Allogeneic or autologous bone marrow transplantation for acute lymphoblastic leukemia in first complete remission. Bone Marrow Transplantation 5(1): 7-12, 1990