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Amino acid balance anti imbalance. V. Effect of an amino acid imbalance involving niacin on liver pyridine nucleotide concentration in the rat



Amino acid balance anti imbalance. V. Effect of an amino acid imbalance involving niacin on liver pyridine nucleotide concentration in the rat



Jour Nutrition: 302-308



The effects of an amino acid imbalance on growth and liver pyridine nucleotide concentrations were determined in rats fed niacin-deficient diets containing 8% of casein. Growth depressions caused by adding threonine or 6% of gelatin were prevented by niacin supplementation, but those caused by adding 12% of gelatin were not. Liver pyridine nucleotide concentrations were not low even in severe growth depression. They were unaffected by niacin supplementation. The growth depressions caused by threonine or gelatin were prevented by supplementation with tryptophan. The latter increased the liver pyridine nucleotide concentration when the imbalance was caused by threonine, but not when it was caused by gelatin. The conclusion has been drawn from these results and those of other investigators that imbalances involving niacin and tryptophan are true amino acid imbalances comparable with those demonstrated in diets not deficient in niacin, and that the involvement of niacin is secondary.

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Accession: 029988856

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PMID: 13772885


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