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An evaluation of sustained-release molybdenlzed ferrous sulfate in iron-deficiency anemia of pregnancy



An evaluation of sustained-release molybdenlzed ferrous sulfate in iron-deficiency anemia of pregnancy



Jour New Drugs 3(3): 155-160



A 1-year study was carried out in an original total of 355 pregnant patients to compare the effectiveness of a sustained-release capsule of molybdenized FeSO4 and a conventional capsule of FeSO4 in the treatment of Fe deficiency anemia. Adequate observations were made in 137 patients who were treated with the sustained-release form of Fe and in 68 who were given the conventional Fe preparation. Measurements of hematocrit, hemoglobin level, and red blood cell count were performed biweekly until term and again at 6 weeks postpartum. The observed results suggest that, in iron deficiency anemia of pregnancy, administration of the sustained-release form of Fe is associated with an apparently greater and more uniform hematologic response than that observed with the conventional capsular dosage form of FeSO4. Side effects occurred chiefly as digestive complaints in 16% of all patients treated with the sustained-release Fe preparation, and in 27% of those treated with the ferrous sulfate capsule. Side effects necessitated discontinuance of medication in 19% of those given the conventional oral dosage form, but in only 6% of those who received the sustained-release Fe preparation.

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Accession: 030021531

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PMID: 14051959


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