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An evaluation of the efficacy of gamma globulin in the prophylaxis of infectious hepatitis in Prague, 1953-1956



An evaluation of the efficacy of gamma globulin in the prophylaxis of infectious hepatitis in Prague, 1953-1956



Jour Hygiene Epidemiol Microbiol and Immunol czechoslovakia 1(4): 413-422



Gamma-globulin was administered to 48,412 subjects exposed to fectious hepatitis in Prague from 1953-1956; 45,546 of these were children under the age of 15 and 30,059 were schoolchildren, most of them between the ages of 6 and 10. Among the subjects immunized with gamma-globulin who were followed up for at least half a year after immunization, a total of 147 contracted infectious hepatitis. The majority of these, however, were taken ill in the 1st few days after the administration of gamma-globulin; 48% within 7 days and 63% within 10 days, presumably before the gamma-globulin had taken effect. When gamma-globulin is administered during the incubation period, its effectiveness increases with decrease in length of time after infection. The number of new cases fell to half when the gamma-globulin was given by the 5th day and to 1/4 by the 10th day after exposure, according to an exponential curve. The increase in new cases between the 17th and 36th day could be explained as secondary cases to whom gamma-globulin was administered on approximately the 5th day after index cases. Four selected schools with a long disease history showed 9 new cases after the 45th day of administration, probably developed after the gamma-globulin had ceased to be effective. The morbidity rate of infectious hepatitis has been as high as 670 in 100,000 (1951). The morbidity rate in the 0-15 year old untreated group was 0.75% compared to 0.12% in the group of gamma-globulin-treated pupils. Thus, protection was considered 6-fold.

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Accession: 030021887

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PMID: 13525742


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