An expeditious synthesis of dolastatin 10

Tomioka, K.; Kanai, M.; Koga, K.

Tetrahedron Letters 32(21): 2395-2398

1991


ISSN/ISBN: 0040-4039
DOI: 10.1016/s0040-4039(00)79932-1
Accession: 030023753

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Abstract
Total synthesis of dolastatin 10 (1) was completed by developing an efficient synthesis of two key amino acid components, Dil (6) and Dap (11), and subsequent stepwise coupling of five amino acid components from C-terminal Doe.