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Chapter 30,024

An expeditious synthesis of dolastatin 10

Tomioka, K.; Kanai, M.; Koga, K.

Tetrahedron Letters 32(21): 2395-2398

1991

ISSN/ISBN: 0040-4039
DOI: 10.1016/s0040-4039(00)79932-1
Accession: 030023753
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Total synthesis of dolastatin 10 (1) was completed by developing an efficient synthesis of two key amino acid components, Dil (6) and Dap (11), and subsequent stepwise coupling of five amino acid components from C-terminal Doe.

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Related References

Poncet, J.; Busquet, M.; Roux, F.; Pierré, A.; Atassi, G.; Jouin, P. 1998: Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15 Journal of Medicinal Chemistry 41(9): 1524-1530
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