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An experimental approach to action of genes at the agouti locus in the mouse HI Transplants of newborn Aw, A-, and at- skin to Ay-, A- and aa hosts



An experimental approach to action of genes at the agouti locus in the mouse HI Transplants of newborn Aw, A-, and at- skin to Ay-, A- and aa hosts



J Exp Zool: 189-196



A study on the action of genes at the agouti locus in the mouse has been completed. The fate of black, yellow, yellow-bellied agouti and agouti pigment cells in agouti, yellow-bellied agouti and black-and-tan hair follicles which were either of the same or different tract origin was established. The results are in accord with those reported previously and indicate that the agouti locus genotype of the receiving hair follicle determines whether a melanocyte will produce eumelanin or pheomelanin. The receiving hair follicle also determines the pattern of pigmentation since the typical agouti pattern results when yellow and black melanoblasts invade dorsal agouti or yellow-bellied agouti hair bulbs. In black-and-tan and yellow-bellied agouti animals ventrality and dorsality are not important, per se, but together with their genetic constitution present different follicular environments which affect the expression of melanocytes. Evidence is presented indicating that the P-locus acts autonomously in the melanocyte.

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