+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Analysis of the spinal excitatory action of pentylenetetrazol

Journal of Pharmacology and Experimental Therapeutics 132: 245-250

Analysis of the spinal excitatory action of pentylenetetrazol

The effects of pentylenetetrazol (Metrazol) were studied in 39 spinal cord experiments in unanesthetized cats. The doses employed (20 to 60 mg/kg) generally reduced the monosynaptic spike and increased polysynaptic activity. The effects of Metrazol on synaptic recovery in the 2N pathway were complex recovery was enhanced at stimulus intervals less than 200 milliseconds and decreased at longer intervals. Recovery processes of the motoneuron were not directly affected by the drug. The results suggest that Metrazol enhances synaptic recovery by a presynaptic action but that this effect is modified by stimulation of interneuronal systems which are primarily inhibitory. Metrazol enhanced recurrent inhibition. The results indicate that the drug increases the intensity and duration of evoked Renshaw cell discharges. The effect of Metrazol to stimulate inhibitory systems is discussed in relation to the cerebral versus the spinal locus of its convulsant action. All the effects of Metrazol were antagonized by appropriate doses of trimethadione.

(PDF 0-2 workdays service: $29.90)

Accession: 030067807

PMID: 13761666

Related references

Effects of analgesic-antipyretics on the spinal reflex potentials in cats: an analysis of the excitatory action of aminopyrine. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 100(5): 383-390, 1992

Differentiation of supraspinal and spinal sites of imipramine action upon spinal inhibitory and excitatory systems. Pflugers Archiv 307(2): R120-R121, 1969

Analysis of the convulsant action of pentylenetetrazol. Experientia 25(4): 382-383, 1969

Excitatory action of TRH on spinal motoneurones. Nature 265(5591): 242-243, 1977

An excitatory action of adrenaline, noradrenaline, and 5-hydroxytryptamine on the spinal cord. Journal of Physiology 185(2): 445-454, 1966

Convergence of excitatory and inhibitory action on interneurones in the spinal cord. Ucla Forum in Medical Sciences 11: 231-265, 1969

Cardiac sympatho-excitatory action of PVN-spinal oxytocin neurones. Autonomic Neuroscience 147(1-2): 80-85, 2009

Effects of p chlorophenyl alanine on the substance p excitatory action in the cat spinal cord. Pharmacologist 22(3): 204, 1980

Convergence of excitatory and inhibitory action on inter neurons in the spinal cord. UCLA (University of California Los Angeles) Forum in Medical Sciences : 231-265, 1970

The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord. Experimental Brain Research 45(1-2): 151-156, 1982