Anomalous distribution of antimony in white rats following the administration of tartar emetic
Ness, A.T.; Brady, F.J.
Journal of Pharmacology and Experimental Therapeutics 90(2): 174-180
ISSN/ISBN: 0022-3565 PMID: 20249079 Accession: 030092961
Dogs and rats were injected with tartar emetic prepared from radioactive Sb. Sb concs. in the blood and tissues of rats were considerably different from those in dogs and, judged by available data, were also different from concs. encountered in man, white mice, cotton rats, and hamsters. In white rats, the blood Sb is characterized by an increasing conc. beginning at 8 hrs. and lasting at least for 72 hrs. This is in contrast to that in man and in the dog in which the conc. is decreasing to very low levels at these intervals. There is some indication that the Sb compd. appearing in the blood of the white rat at later intervals is considerably less toxic to the rat than its tartar emetic precursor. It is suggested that results obtained in screening antimonial compds. in white rats be interpreted with caution until more is learned of the phenomenon.