Antagonism of insulin-induced gastrointestinal hypermotility in the rat

Lish, P.M.; Peters, E.L.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 94(4): 664-668


ISSN/ISBN: 0037-9727
PMID: 13431914
DOI: 10.3181/00379727-94-23045
Accession: 030095848

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The distribution of a charcoal mix in the gastrointestinal tract of the insulin treated rat is described. Effects of a variety of antipropulsive and autonomic blocking agents on the propulsion stimulating effects of insulin were determined. Insulin induced hyperpropulsion was 12 to 37 times more susceptible than normal propulsion to inhibition by atropine-like and papaverine-like agents. Administration of hexamethonium, local anesthetics or adrenergic blockers, but not an antihistamine agent, also inhibited the insulin effect.