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Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa in rodents in vitro and in vivo interactions with benzodiazepine binding sites



Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa in rodents in vitro and in vivo interactions with benzodiazepine binding sites



Psychopharmacology 7(3): 351-360



Rationale: <i>Polygala sabulosa</i>, a folk medicine, presents dihydrostyryl-2-pyrones (DST) and styryl-2-pyrones (STY), compounds structurally similar to kavalactones. Our previous study showed that the ethyl acetate fraction (EA) and these constituents present anxiolytic-like, hypno-sedative, and anticonvulsant effects in mice.

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Accession: 030116070

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DOI: 10.1007/s00213-007-1037-z


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Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites. Psychopharmacology 197(3): 351-360, 2008

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