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Appositional bone formation in canine bone a quantitative study using tetracycline markers

Appositional bone formation in canine bone a quantitative study using tetracycline markers

J Anat 98(4): 665-677

The linear rate in [mu]/day at which bone is deposited (appositional growth rate) on the growing surfaces of osteones and trabeculae in canine compact and cancellous bone has been measured microscopically by means of single tetracycline markers (Harris, W.H. Nature, 188, 1038-9). Appositional growth rate in forming osteones and on trabeculae is of a wide range which is constant in the variety of skeletal sites studied in individual animals but the growth process is slower in older animals. In a puppy the appositional growth rate was found to be approximately 2.0 [mu]/day, in a 2-year old dog, 1.5 [mu]/day and 1.0 [mu]/day in an old dog. In forming osteones the growth rate declines as the osteone reaches completion and the canal diameter decreases; a direct relationship exists between the growth rate and the diameter of the concentric tetracycline markers in the labelled osteones. This correlation can be used to provide a correlation constant for a population of osteones and this technique should be of value in the study of factors affecting osteoblastic function.

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Accession: 030159339

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