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Asymmetric total syntheses of -coronafacic acid and -coronatine



Asymmetric total syntheses of -coronafacic acid and -coronatine



Bioscience Biotechnology & Biochemistry 61(4): 752-753



An asymmetric total synthesis of (+)-coronafacic acid, starting from (R)-(+)-4-acetoxy-2-cyclopen-1-one as a chiral source, was accomplished. Construction of the 1-hydrindanone framework was carried out by using intramolecular 1,6-conjugate addition as the key step. Coupling between (+)-coronafacic acid and protected coronamic acid, and subsequent deprotection provided (+)coronatine. This is the first asymmetric total synthesis of (+)coronatine.

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Accession: 030213898

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DOI: 10.1271/bbb.61.752


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