Atrial natriuretic peptide release responds to atrial stretch and not to atrial pressure: observations during pericardiocentesis in a young woman
Ong, A.C.; Handler, C.E.; Slater, J.D.
European Heart Journal 11(4): 368-371
ISSN/ISBN: 0195-668X PMID: 2139611 Accession: 030219576
The effect of pericardiocentesis on the plasma concentration of atrial natriuretic peptide was studied in a patient with cardiac tamponade. Plasma atrial natriuretic peptide concentrations rose sharply from 42 pmol l-1 to a maximum of 150 pmol l-1 with a corresponding fall in mean right atrial pressure from 20 mmHg to 6 mmHg. Our results suggest that atrial 'stretch' (or transmural pressure) rather than atrial pressure per se, is the primary stimulus for atrial natriuretic peptide release in man.