+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Barrett's esophagus: current and future management

Barrett's esophagus: current and future management

Comprehensive Therapy 20(1): 36-43

Barrett's esophagus is considered to be a preneoplastic condition associated with chronic reflux esophagitis. The risk of neoplasia is difficult to assess but appears to be increased by about 40-fold with an incidence of 1:200 patient years. Diagnosis of Barrett's esophagus is made by endoscopy with biopsy of the suspected area. Barrett's is histologically confirmed by the presence of specialized epithelium (intestinal metaplasia). Histologic findings of low-grade dysplasia and high-grade dysplasia have increased neoplastic risks. The development of cancer within a Barrett's esophagus appears to be related to a sequence of molecular events beginning with the loss of the tumor suppressor gene p53 and followed by the loss of the 5q chromosome. Current management of Barrett's esophagus includes controlling reflux esophagitis and following selected patients with surveillance biopsies. Surgical resection has been advocated for patients with high-grade dysplasia, although this has not been proven to be a cost-effective strategy. Prospective management options include long-term omeprazole use, flow cytometry, endosonography, laser-induced fluorescence, photodynamic therapy, and argon laser therapy. However, long-term observation is needed to determine whether these approaches can impact upon cancer development.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 030256269

Download citation: RISBibTeXText

PMID: 8137618

Related references

Barrett's esophagus. Current assessment and future perspectives. Gastroenterology Clinics of North America 19(3): 733-744, 1990

Endoluminal Treatment of Barrett's Esophagus: Current and Future Prospects. Therapeutic Advances in Gastroenterology 2(5): 261-272, 2009

Endoscopic imaging in Barrett's esophagus: current practice and future applications. Annals of Gastroenterology 25(2): 89-95, 2012

Screening and surveillance for Barrett's esophagus: current issues and future directions. Current Opinion in Gastroenterology 28(4): 377-381, 2012

Current management of Barrett's esophagus. Annales de Chirurgie 52(5): 399-401, 1998

Advanced endoscopic imaging for Barrett's Esophagus: current options and future directions. Current Gastroenterology Reports 14(3): 216-225, 2012

Barrett's esophagus: current and future role of endosonography and optical coherence tomography. Diseases of the Esophagus 17(2): 118-123, 2004

Current Strategies in the management of Barrett's esophagus. Current Gastroenterology Reports 7(3): 196-201, 2005

Dysplasia in Barrett's esophagus: limitations of current management strategies. American Journal of Gastroenterology 100(4): 927-935, 2005

Radiofrequency ablation in the management of Barrett's esophagus: present role and future perspective. Expert Review of Medical Devices 10(4): 509-517, 2014

Barrett's esophagus: A historical perspective, an update on core practicalities and predictions on future evolutions of management. Journal of Gastroenterology and Hepatology 26 Suppl 1: 11-30, 2011

Critical reappraisal of current surveillance strategies for Barrett's esophagus: analysis of a large German Barrett's database. Diseases of the Esophagus 21(8): 685-689, 2008

Adenocarcinoma of the lower esophagus with Barrett's esophagus or without Barrett's esophagus: differences in patients' survival after preoperative chemoradiation. Diseases of the Esophagus 22(1): 32-41, 2008

BRAF V600E Confers Male Sex Disease-Specific Mortality Risk in Patients With Papillary Thyroid Cancer. Journal of Clinical Oncology 2018785097-Jco2018785097, 2018

Evaluation of the risk of malignant transformation in Barrett esophagus. Management before detection of a dysplastic lesion on Barrett's mucosa. Annales de Pathologie 14(5): 296-302, 1994