+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Barriers to recruiting underrepresented populations to cancer clinical trials: a systematic review



Barriers to recruiting underrepresented populations to cancer clinical trials: a systematic review



Cancer 112(2): 228-242



Racial and ethnic minorities, older adults, rural residents, and individuals of low socioeconomic status are underrepresented among participants in cancer-related trials. The authors conducted a systematic review to determine the barriers to participation of underrepresented populations in cancer-related trials. Their search included English-language publications that reported original data on the recruitment of underrepresented groups to cancer treatment or prevention trials between 1966 and December 2005 in multiple electronic databases. They also hand-searched titles in 34 journals from January 2003 to December 2005 and they examined reference lists for eligible articles. Titles and abstracts were reviewed to identify relevant studies. Data on barriers to participation were synthesized both qualitatively and based on statistically significant associations with trial enrollment. Of 5257 studies that were cited, 65 studies were eligible for inclusion in the current analysis, including 46 studies on recruitment into cancer therapeutic trials, 15 studies on recruitment into prevention trials, and 4 studies on recruitment into both prevention and treatment trials. Numerous factors were reported as barriers to participation in cancer-related trials. However, only 20 of the studies reported statistically significant associations between hypothesized barriers and enrollment. The available evidence had limitations in quality regarding representativeness, justification of study methods, the reliability and validity of data-collection methods, potential for bias, and data analysis. The results indicated that underrepresented populations face numerous barriers to participation in cancer-related trials. The current systematic review highlighting the literature on recruitment of underrepresented populations to cancer trials and may be used as the evidence base toward developing an agenda for etiologic and intervention research to reduce the disparities in participation in cancer-related trials.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 030256719

Download citation: RISBibTeXText

PMID: 18008363

DOI: 10.1002/cncr.23157


Related references

Strategies addressing barriers to clinical trial enrollment of underrepresented populations: a systematic review. Contemporary Clinical Trials 39(2): 169-182, 2014

Older cancer patients in cancer clinical trials are underrepresented. Systematic literature review of almost 5000 meta- and pooled analyses of phase III randomized trials of survival from breast, prostate and lung cancer. Cancer Epidemiology 51: 113-117, 2017

A Qualitative Study Exploring Barriers and Facilitators of Enrolling Underrepresented Populations in Clinical Trials and Biobanking. Frontiers in Cell and Developmental Biology 7: 74, 2019

Provider roles in the recruitment of underrepresented populations to cancer clinical trials. Cancer 109(3): 465-476, 2007

Effectiveness of strategies to recruit underrepresented populations into cancer clinical trials. Clinical Trials 3(2): 133-141, 2006

Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. Journal of Clinical Oncology 23(13): 3112-3124, 2005

Knowledge and access to information on recruitment of underrepresented populations to cancer clinical trials. Evidence Report/Technology Assessment 2005(122): 1-11, 2005

Defining "success" in recruitment of underrepresented populations to cancer clinical trials: moving toward a more consistent approach. Cancer 106(6): 1197-1204, 2006

Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors. Lancet. Oncology 7(2): 141-148, 2006

Recruiting minorities where they receive care: Institutional barriers to cancer clinical trials recruitment in a safety-net hospital. Contemporary Clinical Trials 30(6): 552-559, 2009

Barriers for conducting clinical trials in developing countries- a systematic review. International Journal for Equity in Health 17(1): 37, 2018

Barriers to participant retention in knee osteoarthritis clinical trials: a systematic review. Seminars in Arthritis and Rheumatism 42(4): 346-354, 2013

Barriers to recruiting ethnic minorities to mental health research: a systematic review. International Journal of Methods in Psychiatric Research 23(1): 36-48, 2014

Difficulties in recruiting older people in clinical trials: an examination of barriers and solutions. Vaccine 28(4): 901-906, 2010

Challenges and opportunities in recruiting and retaining underrepresented populations into health promotion research. Gerontologist 43 Spec no 1: 37-46, 2003