+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition

Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition

American Journal of Clinical Pathology 129(6): 948-951

We measured analytes in collapsed Boston Marathon runners to compare with changes in asymptomatic runners. Of collapsed runners at the 2007 marathon, 18.2% had a measurable cardiac troponin T (cTnT) value with a mean postrace level of 0.017 ng/mL (0.017 microg/L; SD, 0.02 ng/mL [0.02 microg/L]). Three subjects had cTnT values above the cutoff (0.10 ng/mL [0.10 microg/L]) typically used for the diagnosis of acute myocardial infarction. The mean and median N-terminal pro-B-type natriuretic peptide levels were 73 ng/L (SD, 77.3 ng/L) and 54.3 ng/L (interquartile range, 22.8-87.3 ng/L), respectively, in collapsed runners. Only 4.9% had values more than the age-specific normal value (<125 ng/L for subjects younger than 75 years). In collapsed subjects at the 2006 marathon, 18.0% had an abnormal sodium value, including 18 cases of hypernatremia and 7 cases of hyponatremia. The ionized calcium level was low in 49% of subjects, and the ionized magnesium level was low in 19.5% and elevated in 1 subject. The blood lactate level was elevated in 95% of subjects. The frequency of elevated postrace cTnT levels in collapsed athletes after endurance exercise is similar to that in asymptomatic runners. Other metabolic abnormalities, including hypernatremia, hyponatremia, low ionized calcium and magnesium levels, and lactic acidosis may contribute to muscle fatigue and collapse.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 030413728

Download citation: RISBibTeXText

PMID: 18480012

DOI: 10.1309/4l0m60mgaqbchmv7

Related references

High-sensitivity troponin T in marathon runners, marathon runners with heart disease and collapsed marathon runners. Scandinavian Journal of Medicine and Science in Sports 29(5): 663-668, 2019

The impact of exercise intensity on the release of cardiac biomarkers in marathon runners. European Journal of Applied Physiology 111(12): 2961-2967, 2011

Sodium status of collapsed marathon runners. Archives of Pathology & Laboratory Medicine 129(2): 227-230, 2005

Correlation of Cardiac Markers and Biomarkers With Blood Pressure of Middle-Aged Marathon Runners. Journal of Clinical Hypertension 17(11): 868-873, 2015

Elevated serum cardiac markers in asymptomatic marathon runners after competition: is the myocardium stunned?. Cardiology 88(6): 487-491, 1997

Clinical and biochemical characteristics of collapsed ultra-marathon runners. Medicine and Science in Sports and Exercise 26(9): 1095-1101, 1994

Changes in Cardiac Biomarkers Post-Marathon in Male and Female Runners Across the Age Spectrum: 3633 Board #72 June 4, 9: 30 AM - 11: 00 AM. Medicine and Science in Sports and Exercise 48(5 Suppl 1): 1009-1009, 2016

Positive rapid assays for cardiac markers including troponin I in asymptomatic marathon runners after competition. Circulation 96(8 Suppl. ): I85-I86, 10/21/97, 1997

The evaluation of cardiac complaints in marathon runners. Journal of Emergency Medicine 36(4): 369-376, 2009

Exercise-induced changes of left ventricular diastolic function in postmenopausal amateur marathon runners: assessment by echocardiography and cardiac biomarkers. European Journal of Preventive Cardiology 21(6): 782-790, 2014

Do non-elite older runners slow down more than younger runners in a 100 km ultra-marathon?. Bmc Sports Science Medicine and Rehabilitation 7: 1, 2015

Myocardial function in older male amateur marathon runners: assessment by tissue Doppler echocardiography, speckle tracking, and cardiac biomarkers. Journal of the American Society of Echocardiography 22(7): 803-809, 2009

Solar Ultraviolet Radiation Exposure of South African Marathon Runners During Competition Marathon Runs and Training Sessions: A Feasibility Study. Photochemistry and Photobiology 91(4): 971-979, 2016

Changes in blood morphology and chosen biochemical parameters in ultra-marathon runners during a 100-km run in relation to the age and speed of runners. International Journal of Occupational Medicine and Environmental Health 29(5): 801-814, 2016

Exertional dysnatremia in collapsed marathon runners: a critical role for point-of-care testing to guide appropriate therapy. American Journal of Clinical Pathology 132(3): 336-340, 2009