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Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell


Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell



Annals of the new York Academy of Sciences 713: 41-48



ISSN/ISBN: 0077-8923

PMID: 8185204

DOI: 10.1111/j.1749-6632.1994.tb44051.x

Figure 1 summarizes our current concept of a signaling mechanism to explain agonist-induced Ca2+ entry in the pancreatic acinar cell. We propose that cGMP can modulate Ca2+ entry under conditions of internal Ca2+ store depletion and that the NO signaling system may be involved in coupling Ca2+ depletion to cGMP formation. The finding that Ca2+ entry after Ca2+ store depletion can occur with no elevation in [Ca2+]i37 raises the possibility that alternative signaling pathways may converge to stimulate cGMP formation or that additional messengers may activate plasmalemmal Ca2+ entry mechanisms in parallel.

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Accession: 030443913

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