+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chiral resolution of cationic drugs of forensic interest by capillary electrophoresis with mixtures of neutral and anionic cyclodextrins



Chiral resolution of cationic drugs of forensic interest by capillary electrophoresis with mixtures of neutral and anionic cyclodextrins



Analytical Chemistry 66(22): 4019-4026



Chiral resolution of a number of cationic drugs of forensic interest (amphetamine, methamphetamine, cathinone, methcathinone, cathine, cocaine, propoxyphene, and various alpha-hydroxyphenethylamines) is achieved via capillary electrophoresis (CE) with added cyclodextrins (CDs), including novel mixtures of neutral and anionic CDs. In the latter studies, resolution and migration speed are readily adjusted by varying the ratio of the two added CDs, as the anionic CD acts as a counter-migrating complexing reagent. The neutral CD, heptakis(2,6-di-O-methyl)-beta-CD, was found suitable for the analysis of illicit cocaine and khat leaves (Catha edulis Forsk), which contain (-)-alpha-aminopropiophenone ((-)-cathinone), (+)-norpseudoephedrine (cathine), (-)-norephedrine, and trace levels of the phenylpentenylamines (+)-merucathinone, (+)-merucathine, and possibly (-)-pseudomerucathine. The use of mixtures of the neutral and the anionic CD (beta-CD sulfobutyl ether IV) was found suitable for the analysis of illicit amphetamine, methamphetamine, methcathinone, and propoxyphene. A model is presented for the impact of mixtures of neutral and anionic CDs on migration behavior and chiral resolution in CE.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 030520556

Download citation: RISBibTeXText

PMID: 7810901

DOI: 10.1021/ac00094a026


Related references

Enantioseparation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using mixtures of anionic and uncharged beta-cyclodextrins as chiral additives. Electrophoresis 18(6): 1013-1018, 1997

Chiral separation of anionic and neutral compounds using a hepta-substituted cationic beta-cyclodextrin as a chiral selector in capillary electrophoresis. Electrophoresis 23(9): 1314-1319, 2002

Optimization of enantiomeric separations for basic compounds in capillary zone electrophoresis using neutral and anionic cyclodextrins as chiral selectors. Biomedical Chromatography 9(6): 265-266, 1995

Chiral resolution of functionalized piperidine enantiomers by capillary electrophoresis with native, alkylated and anionic beta-cyclodextrins. Journal of Chromatography A 796(2): 375-383, 1998

When a truck becomes a motorcycle: the impact of sample load on a chiral capillary electrophoresis separation using mixtures of neutral and sulfated cyclodextrins. Electrophoresis 20(13): 2664-2669, 1999

Determination of trace enantiomeric impurities in chiral compounds by capillary electrophoresis with uncoated, cationic, anionic and neutral surface modified capillaries. Journal Of Chromatography A. 817(1-2): 83-90,. 21, 1998

Enantioseparation of acidic drugs by capillary electrophoresis using dual systems with mixtures of charged and neutral cyclodextrins. Biomedical Chromatography 12(3): 131-132, 1998

Enantiomer separation of drugs by capillary electrophoresis using mixtures of beta-cyclodextrin sulfate and neutral cyclodextrins. Electrophoresis 20(1): 189-197, 1999

A comparison of HPLC and capillary electrophoresis for the enantiomeric resolution of selected chiral drugs using cyclodextrins. Journal of Pharmacy & Pharmacology 45(Suppl. 2): 1128, 1993

Comparison of chiral separation of basic drugs in capillary electrophoresis and liquid chromatography using neutral and negatively charged cyclodextrins. AnalyticaChimicaActa645(1-2):98, 2009

Use of cyclodextrins in capillary electrophoresis for the chiral resolution of some 2-arylpropionic acid non-steroidal anti-inflammatory drugs. Journal of Chromatography A 694(1): 297-305, 1995

Use of 1H-NMR spectroscopy to determine the enantioselective mechanism of neutral and anionic cyclodextrins in capillary electrophoresis. Journal of Pharmaceutical & Biomedical Analysis 15(9-10): 1603-1619, 1997

Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector. Journal of Capillary Electrophoresis 2(5): 213-217, 1995

Chiral separation of monoterpenes using mixtures of sulfated beta-cyclodextrins and alpha-cyclodextrin as chiral additives in the reversed-polarity capillary electrophoresis mode. Journal of Chromatography A 759(1-2): 149-155, 1997

Neutral and anionic cyclodextrins in capillary zone electrophoresis: enantiomeric separation of ephedrine and related compounds. Electrophoresis 15(6): 799-803, 1994