Section 31
Chapter 30,816

Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

Okada, Y.; Konomi, H.; Yada, T.; Kimata, K.; Nagase, H.

Febs Letters 244(2): 473-476


ISSN/ISBN: 0014-5793
PMID: 2920840
DOI: 10.1016/0014-5793(89)80586-1
Accession: 030815968

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The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called gelatinase’) could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.

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