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Demonstration of beta 2 mediated positive chronotropic action of isoproterenol in anesthetized dogs comparison with selective beta 1 agonist t 0509






Japanese Journal of Pharmacology 52(SUPPL 1): 247P

Demonstration of beta 2 mediated positive chronotropic action of isoproterenol in anesthetized dogs comparison with selective beta 1 agonist t 0509



Accession: 030823104



Related references

Yamazaki, J.; Sugimoto, T.; Yabana, H.; Nagao, T., 1994: Hemodynamic and coronary vasodilative properties of a selective and full beta-1-adrenoceptor agonist, T-0509, in comparison with isoproterenol in anesthetized dogs. Recently, the beta-1-adrenoceptor was shown to mediate direct coronary vasodilation independent of metabolic demand in canine arrested heart preparation. To investigate the beta-1-adrenoceptor-mediated direct vasodilation in a beating heart prepar...

Yamazaki, J.; Sugimoto, T.; Yabana, H.; Nagao, T., 1994: Hemodynamic and coronary vasodilative properties of a selective and full beta 1-adrenoceptor agonist, T-0509, in comparison with isoproterenol in anesthesized dogs. Recently, the beta 1-adrenoceptor was shown to mediate direct coronary vasodilation independent of metabolic demand in canine arrested heart preparation. To investigate the beta 1-adrenoceptor-mediated direct vasodilation in a beating heart prepar...

Tofukuji, M.; Yanagisawa, T.; Kurosawa, H.; Ishii, K.; Taira, N., 1993: ICI 147,798 causes insurmountable antagonism against T-0509, a selective beta 1-adrenoceptor agonist, but surmountable antagonism against isoproterenol. In canine right ventricular muscle, the influence of ICI 147,798, a slowly dissociable beta 1-adrenoceptor antagonist, on the positive inotropic effect and cyclic AMP production of T-0509, a selective beta 1-agonist, and isoproterenol, a nonselect...

Yabana H.; Watanabe H.; Narita H.; Nagao T., 1992: Selective and full beta 1 adrenoceptor agonist action of a catechol derivative of denopamine t 0509 in the guinea pig cardiac muscle and trachea comparison with denopamine xamoterol and isoprenaline. The pharmacological actions of T-0509, a 3-hydroxy derivative of denopamine, were studied in various guinea-pig tissues; these effects were compared with those of isoprenaline, denopamine and xamoterol. The intrinsic activities of the positive ino...

Yabana, H.; Watanabe, H.; Narita, H.; Nagao, T., 1992: Selective and full beta 1-adrenoceptor agonist action of a catechol derivative of denopamine (T-0509) in the guinea-pig cardiac muscle and trachea: comparison with denopamine, xamoterol and isoprenaline. 1. The pharmacological actions of T-0509, a 3-hydroxy derivative of denopamine, were studied in various guinea-pig tissues; these effects were compared with those of isoprenaline, denopamine and xamoterol. 2. The intrinsic activities of the positi...

Sato, Y.; Adachi-Akahane, S.; Prados, P.; Imai, K.; Nagao, T., 1995: Desensitization and selective down-regulation of rat cardiac beta 1-adrenoceptors by prolonged in vivo infusion of T-0509, a beta 1-adrenoceptor full agonist. We studied the effects of prolonged infusion of a selective beta 1-adrenoceptor (beta 1AR) full agonist, T-0509 [(-)-(R)-1-(3,4-dihydroxyphenyl)-2-[(3,4- dimethoxyphenethyl)amino]ethanol hydrochloride], with regard to its inotropic effect in vivo...

Oshima T.; Koike H.; Nakayama K., 1972: Effects of cs 359 a new beta adrenergic blocking agent on positive chronotropic responses to exercise and isoproterenol in conscious dogs. Japanese Journal of Pharmacology 22(SUPPL): 24

Bonelli, J., 1978: Demonstration of 2 different types of beta 1 receptors in man selective blockade of the positively inotropic and the positively chronotropic effect of isoproterenol. The hemodynamic effect of a .beta.-receptor blockade with mepindolol, a noncardioselective .beta.-receptor blocker, was studied in 6 male test subjects age 25-30 yr with an increasing dose of isoproterenol. The cardiac output per min, the heart ra...

Yanagisawa T.; Kurosawa H.; Sato E.; Taira N., 1990: Antagonism between denopamine and t 0509 a selective beta 1 full agonist in canine ventricular muscle. Japanese Journal of Pharmacology 52(SUPPL 1): 247P

Tagami, H.; Yamazaki, J.; Nagao, T., 1995: Differential effects of selective beta 1-agonist stimulation on epi- and endocardial oxygen tension in anesthetized dogs. We investigated the effects of selective beta 1 adrenoceptor stimulation on oxygen tension (pO2) in the myocardium of anesthetized dogs. A beta 1-selective full agonist, T-0509 (0.01-0.05 microgram/kg, i.v.), caused positive inotropic and chronotr...