+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of acute unilateral renal denervation on renal hemodynamics in spontaneously hypertensive rats



Effect of acute unilateral renal denervation on renal hemodynamics in spontaneously hypertensive rats



Autonomic and Autacoid Pharmacology 28(2-3): 87-94



1 This study was undertaken to characterize the renal responses to acute unilateral renal denervation in anaesthetized spontaneously hypertensive rats (SHR) by examining the effect of acute unilateral renal denervation on the renal hemodynamic responses to a set of vasoactive agents and renal nerve stimulation. 2 Twenty-four male SHR rats underwent acute unilateral renal denervation and the denervation was confirmed by significant drop (P < 0.05) in renal vasoconstrictor response to renal nerve stimulation along with marked diuresis and natriuresis following denervation. After 7 days treatment with losartan, the overnight fasted rats were anaesthetized (sodium pentobarbitone, 60 mg kg(-1) i.p.) and renal vasoconstrictor experiments were performed. The changes in the renal vasoconstrictor responses were determined in terms of reductions in renal blood flow caused by renal nerve stimulation or intrarenal administration of noradrenaline, phenylephrine, methoxamine and angiotensin II. 3 The data showed that there was significantly (all P < 0.05) increased renal vascular responsiveness to the vasoactive agents in denervated rats compared to those with intact renal nerves. In losartan-treated denervated SHR rats, there were significant (all P < 0.05) reductions in the renal vasoconstrictor responses to neural stimuli and vasoactive agents as compared with that of untreated denervated SHR rats. 4 The data obtained in denervated rats suggested an enhanced sensitivity of the alpha(1)-adrenoceptors to adrenergic agonists and possible increase of AT(1) receptors functionality in the renal vasculature of these rats. These data also suggested a possible interaction between sympathetic nervous system and renin-angiotensin system in terms of a crosstalk relationship between renal AT(1) and alpha(1)-adrenoceptor subtypes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 031061048

Download citation: RISBibTeXText

PMID: 18598290

DOI: 10.1111/j.1474-8673.2008.00421.x


Related references

Effect of acute propanil exposure on the immune response of c57bl 6 mice. Fundamental and Applied Toxicology 12(4): 757-764, 1989

Quantitative determination of diastolic suction using vector flow mapping. Life Sciences 93(25-26): e20, 2013

Effect of renal denervation and alpha-adrenergic blockade on sodium excretion in dogs with chronic ligation of the common bile duct. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 146(3): 764-770, 1974

Effect of carvacrol on growth and toxin production by aspergillus flavus and aspergillus parasiticus. Sciences des Aliments 11(2): 361-370, 1991

Effect of Azosemide on the in vitro Perfused Thick Ascending Limb of Henle’s Loop from the Mouse. Pharmacology 41(4): 195-199, 1990

Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. Clinical and Experimental Hypertension 31(4): 342-354, 2009

Effect of acute tri o tolyl phosphate exposure on 2 3 cyclic nucleotide 3 phosphohydrolase activity in hen neural tissues. 1988

Acute renal carbuncle. Journal of Urology 118(6): 912-915, 1977

Radiofrequency Ablation for Early-Stage Breast Cancer: Results from Five Years of Follow-Up in a Prospective Multicenter Study. Journal of the American College of Surgeons 225(4): E6-E7, 2017

Effect of renal denervation on the development of hypertension in Dahl-Iwai salt-sensitive rats. Nihon Jinzo Gakkai Shi 33(9): 867-871, 1991

Systemic and regional hemodynamics in normotensive and spontaneously hypertensive rats after the calcium antagonist bayer e 5009. Federation Proceedings 40(3 Part 1): 724, 1981

Renal cell carcinoma with inferior vena caval tumour thrombus: Surgical management and clinical outcomes at a low-volume centre. Surgical Practice 17(1): 2-6, 2013

Effect of renal denervation on elevation of blood pressure in cold-exposed rats. FASEB Journal 8(4-5): A329, 1994

The effect of the removal of gases from stationary culture in the production of tetanus toxin in lathams medium. Revista Latinoamericana de Microbiologia 26(2): 170, 1984

Acute renal failure, prostatitis and SIRS Report of two cases. Journal of the American Society of Nephrology 10(PROGRAM AND ABSTR ISSUE): 149A-150A, 1999