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Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients



Effect of white cell counts on the presence of human herpes simplex virus type-1 in saliva of pediatric oncology patients



Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 105(5): 583-588



The objective of this study was to assess if there is increased herpes simplex virus type 1 (HSV-1) salivary shedding in oncology pediatric patients with severe cytopenia (SC). HSV-1 was detected by real time PCR in saliva samples from oncology pediatric patients (n = 30) during SC and relative cytopenia (RC), and from healthy children (n = 27). The frequency of HSV-1 positive saliva samples was higher in patients with SC as compared to controls (P < .05), and this frequency presented a significant reduction during RC periods (P < .02). The SC group positive for HSV-1 presented both a twofold increase in the neutrophil-to-lymphocyte ratio as compared with SC patients negative for HSV-1 (P < .05), and a positive correlation between neutrophil and lymphocyte counts (P < .05, R = 0.82, R(2) = 0.67). This correlation was not found in oncology patients negative for HSV-1 during SC and RC. Severe cytopenia in oncology pediatric patients could be an important susceptibility factor for increased HSV-1 salivary shedding.

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Accession: 031125176

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PMID: 18442743

DOI: 10.1016/j.tripleo.2007.12.035


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