+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of electro-acupuncture on CNTF expression in spared dorsal root ganglion and the associated spinal lamina II and nucleus dorsalis following adjacent dorsal root ganglionectomies in cats



Effects of electro-acupuncture on CNTF expression in spared dorsal root ganglion and the associated spinal lamina II and nucleus dorsalis following adjacent dorsal root ganglionectomies in cats



Neuropeptides 42(1): 95-106



It is well known that plasticity occurs in deafferented spinal cord, and that electro-acupuncture (EA) could promote functional restoration. The underlying mechanism is, however, unknown. Ciliary neurotrophic factor (CNTF) plays a crucial role in neurite outgrowth and neuronal survival both in vivo and in vitro, and its expression might explain some of the mechanism. In this study, we investigated the effects of EA on CNTF expression in the spared L(6) dorsal root ganglion (DRG), and spinal lamina II at spinal segments L(3) and L(6) as well as nucleus dorsalis (ND) of L(3) spinal segment following removal of L(1)-L(5) and L(7)-S(2) (DRG) in the cat. After ganglionectomies, the total and small-to-medium-sized numbers of immunoreactive neurons decreased at 3 dpo, and returned to the sham-operated level as early as 7 dpo. After EA, immunoreactive neurons in L(6) DRG noticeably increased at 7 dpo, compared with the non-acupunctured group. Notable increase in the large neurons was seen at 14 dpo, while their numbers in L(3) and L(6) spinal cord segments significantly declined at 3 dpo. Those in L(3) segment did not reach the sham-operated level until 14 dpo, but their numbers in L(6) segment returned to the sham-operated level as early as 7 dpo. CNTF immunopositive neurons in the ND of L(3) segment returned to the sham-operated level at 14 dpo. After EA, their number significantly increased as early as 7 dpo in lamina II of L(6) segment, and as late as 14 dpo in ND of L(3) segment. Western blot analysis showed CNTF changes corresponding to those shown in immunohistochemical staining. It is concluded that CNTF expression was involved in the EA promoted plastic changes in L(6) DRG and the associated deafferented spinal lamina and ND.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 031152365

Download citation: RISBibTeXText

PMID: 18023864

DOI: 10.1016/j.npep.2007.09.007


Related references

Effects of electro-acupuncture on IGF-I expression in spared dorsal root ganglia and associated spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomies. Neurochemical Research 34(11): 1993-1998, 2009

Effects of electro-acupuncture on the expression of c-jun and c-fos in spared dorsal root ganglion and associated spinal laminae following removal of adjacent dorsal root ganglia in cats. Neuroscience 140(4): 1169-1176, 2006

Effects of electro-acupuncture on NT-4 expression in spinal dorsal root ganglion, associated segments of the spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomy. 2008

Effects of electro-acupuncture on NT-4 expression in spinal dorsal root ganglion and associated segments of the spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomy. Neuroscience Letters 450(2): 158-162, 2009

Retraction notice to: “Effects of electro-acupuncture on NT-4 expression in spinal dorsal root ganglion and associated segments of the spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomy” [Neurosci. Lett. 450 (2009) 158–162. Neuroscience Letters 528(1): 91-91, 2014

Effects of electro-acupuncture on PDGF expression in spared dorsal root ganglion and associated dorsal horn subjected to partial dorsal root ganglionectomy in cats. Neurochemical Research 33(3): 437-443, 2008

The neurite-outgrowth promoting effect from Clarke's nucleus of cat spinal cord with spared dorsal root preparation under electro-acupuncture stimulation on dorsal root ganglion of chicken embryo. Sheng Li Ke Xue Jin Zhan 26(4): 333-336, 1995

Electro-acupuncture induced NGF, BDNF and NT-3 expression in spared L6 dorsal root ganglion in cats subjected to removal of adjacent ganglia. Neuroscience Research 59(4): 399-405, 2007

Expression of CNTF and PDGF in spared dorsal root ganglion after partial dorsal root rhizotomy. Sichuan Da Xue Xue Bao. Yi Xue Ban 36(2): 176-179, 2005

Expression of GDNF in dorsal root ganglion after partial dorsal root rhizotomy and acupuncture in spared root. Sichuan Da Xue Xue Bao. Yi Xue Ban 34(2): 245-247, 2003

Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy. Neuroscience Letters 431(2): 112-117, 2008

Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy (vol 431, pg 112, 2008). 2007

Impact of acupuncture to IGF-I expression in spared dorsal root ganglion of cats. Sichuan Da Xue Xue Bao. Yi Xue Ban 37(3): 384-386, 2006

C-jun expression in spared dorsal root ganglion following partial dorsal root rhizotomy and acupuncture. Sichuan Da Xue Xue Bao. Yi Xue Ban 34(2): 248-250, 2003

Expression of Sema3A and NP-1 in spinal cord and spared dorsal root ganglion after partial dorsal root rhizotomy of cat. Sichuan Da Xue Xue Bao. Yi Xue Ban 39(1): 48-51, 2008