Efficacy of single-dose liposomal amphotericin B or micafungin prophylaxis in a neutropenic murine model of invasive pulmonary aspergillosis

Lewis, R.E.; Albert, N.D.; Kontoyiannis, D.P.

Antimicrobial Agents and ChemoTherapy 52(11): 4178-4180

2008


ISSN/ISBN: 0066-4804
PMID: 18725439
DOI: 10.1128/aac.00715-08
Accession: 031199860

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Abstract
In a neutropenic murine model of invasive pulmonary aspergillosis, prophylaxis with single doses of liposomal amphotericin B or micafungin at >=5 mg/kg of body weight improved animal survival and suppressed the lung fungal burden for up to 7 days after infection, demonstrating the potential utility of infrequent dosing with these antifungals.