+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Enzymatic oxidation of methyl groups on aromatic heterocycles a versatile method for the preparation of heteroaromatic carboxylic acids

Angewandte Chemie International Edition in English 31(6): 774-775

Enzymatic oxidation of methyl groups on aromatic heterocycles a versatile method for the preparation of heteroaromatic carboxylic acids

Accession: 031263799

DOI: 10.1002/anie.199207741

Related references

Hirashima, S-ichi.; Itoh, A., 2007: Aerobic visible light-oxidation of aromatic methyl groups to carboxylic acids. A catalytic amount of magnesium bromide diethyl etherate ( MgBr2 center dot Et2O) enables us to carry out the aerobic photo-oxidation of a methyl group at the aromatic nucleus to the corresponding carboxylic acid in high yield under irradiation o...

Sugimoto, O.; Arakaki, T.; Kamio, H.; Tanji, K-ichi., 2014: The use of a Mitsunobu reagent for the formation of heterocycles: a simple method for the preparation of 3-alkyl-5-aryl-1,3,4-oxadiazol-2(3H)-ones from carboxylic acids. The reaction of carboxylic acids with Mitsunobu reagents, prepared by the reaction of triphenylphosphine with dialkyl azodicarboxylates, followed by heating at 180-190 °C under solvent-free conditions, afforded 3-alkyl-5-aryl-1,3,4-oxadiazol-2(3H...

Sugai T.; Mori K., 1984: Preparation of r ibuprofen and related carboxylic acids using microbial oxidation of an aromatic hydrocarbon by rhodococcus sp bpm 1613. (R)-2-(4'-Isobutylphenyl)propanoic acid (ibuprofen), (S)-3-(4'-isobutylphenyl)butanoic acid and (S)-4-(4'-isobutylphenyl)pentanoic acid were obtained using microbial oxidation of (.+-.)-1-isobuty-4-(1'-methyloctyl)benzene by Rh...

Kopp, F.; Wunderlich, S.; Knochel, P., 2007: Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids. The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl.LiCl; the resulting double-magnesiated species react with a v...

Ferorelli, S.; Loiodice, F.; Tortorella, V.; Conte-Camerino, D.;, A.M., 2001: Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids. One or two methyl groups have been introduced on the aromatic ring of two chiral clofibric acid analogs, 2-(4-chloro-phenoxy)propanoic and 2-(4-chloro-phenoxy)butanoic acids. The biological activity of the derivatives obtained (3-6) has been evalu...

Chen, C L.; Gratzl, J.S.; Kirkman, A.G.; Potthast, A.; Rosenau, T., 1999: Selective enzymatic oxidation of aromatic methyl groups to aldehydes by oxygen in the presence of a laccase-mediator catalyst. Official Gazette of the United States Patent & Trademark Office Patents 1220(5): 4524, March 30

Perez, H., I.; Luna, H.; Manjarrez, N.; Solis, A.; Nunez, M.-Amelia, 1999: Preparation of (1S)-verbenone, aromatic and alicyclic carboxylic acids by oxidation of aldehydes, primary and secondary alcohols with Nocardia corallina. (1S)-Verbenone, (S)-perillyl acid, cinnamic acid, meta-nitrocinnamic acid, veratric acid and 2-naphthoic acid were prepared, at 1 mM scale, from the corresponding alcohols or aldehydes with whole cells of Nocardia corallina B-276, in yields from 1...

Roduit, J.P.ul; Kalbermatten, G., 2003: Process for the preparation of arylamides of heteroaromatic carboxylic acids. A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: ##STR1## in which each An is nitrogen or CRn (n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that two nitrogen atoms...

Schulte, K.E.; Engelhardt, W., 1955: Acetylene carboxylic acids. V. Enzymatic hydrolysis of methyl esters of short chain alkene and alkine carboxylic acids. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 302(2-3): 73-79

Chornous, V.A.; Bratenko, M.K.; Vovk, M.V.; Sidorchuk, I.I., 2001: Synthesis and antimicrobial properties of hydrazides of pyrazol-4-carboxylic acids and N- hydrazones of aromatic and heteroaromatic aldehydes. Khimiko-Farmatsevticheskii Zhurnal 35(4): 26-28, April