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Ethanol actions and GABAA receptor function in spinal cords from mice lacking the beta3 subunit of the GABAA receptor

Society for Neuroscience Abstracts 24(1-2): 492

Ethanol actions and GABAA receptor function in spinal cords from mice lacking the beta3 subunit of the GABAA receptor

Accession: 031300297

Related references

Hentschke, H.; Benkwitz, C.; Banks, M.I.; Perkins, M.G.; Homanics, G.E.; Pearce, R.A., 2010: Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit. Phasic GABAergic inhibition in hippocampus and neocortex falls into two kinetically distinct categories, GABA(A,fast) and GABA(A,slow). In hippocampal area CA1, GABA(A,fast) is generally believed to underlie gamma oscillations, whereas the contrib...

Banks, M.I.; Homanics, G.E.; Pearce, R.A., 2001: Reduced evoked and spontaneous GABAA,slow IPSCS in mice lacking the beta3 subunit of the GABAA receptor. Introduction: The dendrites of hippocampal CA1 pyramidal cells are targeted by interneurons generating (GABAA,slow) IPSCs several fold slower than persiomatic (GABAA,fast) IPSCs. Previous studies suggest that somatic and dendritic receptors differ...

Delorey, T.M.; Handforth, A.; Asatourian, A.; Homanics, G.; Minassian, B.; Delgado Escueta, A.V.; Olsen, R.W., 1997: Epilepsy in mice lacking the GABAA-receptor beta3 subunit gene. Epilepsia 38(SUPPL 8): 122-123

DeLorey, T.M.; Handforth, A.; Anagnostaras, S.G.; Homanics, G.E.; Minassian, B.A.; Asatourian, A.; Fanselow, M.S.; Delgado-Escueta, A.; Ellison, G.D.; Olsen, R.W., 1998: Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. Angelman syndrome (AS) is a severe neurodevelopmental disorder resulting from a deletion/mutation in maternal chromosome 15q11-13. The genes in 15q11-13 contributing to the full array of the clinical phenotype are not fully identified. This study...

Mihalek, R.; Homanics, G.E., 1998: Behavioral responses to ethanol in mice lacking the delta subunit of the GABAA receptor. Alcoholism Clinical & Experimental Research 22(3 ABSTR SUPPL ): 10A, May

Wong, S.M.; Cheng, G.; Homanics, G.E.; Kendig, J.J., 2001: Enflurane actions on spinal cords from mice that lack the beta3 subunit of the GABA(A) receptor. Background: gamma-Aminobutyric acid type A (GABAA) receptors are considered important in mediating anesthetic actions. Mice lacking the beta3 subunit of this receptor (beta3-/-) have a higher enflurane minimum alveolar concentration (MAC) than wil...

Liljelund, P.; Handforth, A.; Homanics, G.E.; Olsen, R.W., 2005: GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior. The homozygous knockout mouse for the beta3 subunit of the GABAA receptor has been proposed as a model for the neurodevelopmental disorder, Angelman syndrome, based on phenotypic similarities of craniofacial abnormalities, cognitive defects, hyper...

Carlson, S.L.; O'Buckley, T.K.; Thomas, R.; Thiele, T.E.; Morrow, A.Leslie., 2015: Altered GABAA receptor expression and seizure threshold following acute ethanol challenge in mice lacking the RIIβ subunit of PKA. Ethanol causes pathological changes in GABAA receptor trafficking and function. These changes are mediated in part by ethanol activation of protein kinase A (PKA). The current study investigated the expression of the GABAA α1 and α4 subunits and...

Huntsman, M.M.; Porcello, D.M.; Homanics, G.E.; Delorey, T.M.; Olsen, R.W.; Huguenard, J.R., 1998: Reduced inhibitory function in thalamic reticular nucleus in mice devoid of GABAA receptor beta3 subunit gene. Society for Neuroscience Abstracts 24(1-2): 1512

Serafini, R.; Bracamontes, J.; Steinbach, J.H.nry, 2000: Structural domains of the human GABAA receptor beta3 subunit involved in the actions of pentobarbital. 1. This study was conducted to search for the residues of the beta3 subunit which affect pentobarbital action on the gamma-aminobutyric acid type A (GABAA) receptor. Three chimeras were constructed by joining the GABAA receptor beta3 subunit to th...