+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Experiments on a new hollow fiber membrane for immuno isolated transplantation of islets of Langerhans



Experiments on a new hollow fiber membrane for immuno isolated transplantation of islets of Langerhans



Hormone and Metabolic Research. Supplement Series 25: 202-206



Immunoisolated transplantation of xenogeneic islets could solve problems concerning the immunology of islet transplantation. This study presents results from in vitro and in vivo experiments in rodents by the use of a PEEK-hollow fiber. Glucagon secretion of encapsulated islets during a 48-hour-culture period sustained on the same level from day 2 to 28. There were no significant differences in glucose (16.7 mmol/l)-stimulated insulin release after 6, 14 or 28 days in culture. Contrary, intraperitoneal transplantation of 800 encapsulated islets resulted in a normoglycemia of 3.8 days (medium survival time) which was similar to that of not encapsulated controls. It was concluded that a more open ultrastructure of the membrane tested could result in a minimization of the diffusion distance and overcome principle geometric problems of the hollow fiber model.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 031369989

Download citation: RISBibTeXText

PMID: 2088969


Related references

Alginate coating of islets of Langerhans: in vitro studies on a new method for microencapsulation for immuno-isolated transplantation. Acta Diabetologica 29(1): 41-45, 1992

Preliminary experiments on vitrification of isolated rat islets of langerhans. Cryobiology 22(6): 0-603, 1985

Transplantation of isolated islets of langerhans in diabetic dogs results after allogeneic intra portal islet transplantation. Journal of Surgical Research 27(3): 181-192, 1979

Effect of epinephrine and norepinephrine on immuno-reactive insulin secretion from isolated islets of Langerhans. Biochemical Pharmacology 34(7): 985-987, 1985

Transplantation of isolated islets of langerhans into pancreatectomized rats. Diabetologia 9(1): 66, 1973

The role of histocompatibility antigens in transplantation of isolated islets of Langerhans in the rat. Diabetes 42(1): 90-97, 1993

Studies on the culture and transplantation of isolated islets of langerhans of the guinea pig. Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen. Series C. Biological and Medical Sciences 72(2): 157-171, 1969

Transplantation of isolated islets of Langerhans into the liver of diabetic dogs. Zentralblatt für Chirurgie 101(22): 1359-1368, 1976

The cure of streptozotocin diabetes in rats by homo transplantation of isolated intra portally injected langerhans islets or by renal subcapsular transplantation of neo natal pancreases. Diabetologia 13(4): 409-410, 1977

Synthesis of pro insulin and large glucagon immuno reactivity in isolated langerhans islets from encephalomyocarditis virus infected mice. Diabetologia 11(1): 21-26, 1975

Investigations on isolated islets of Langerhans in vitro. XIII. Experiments concerning the preparation conditions with collagenase. Endokrinologie 67(1): 67-78, 1976

Successful transplantation of isolated pancreatic islets of langerhans from an ABO incompatible donor. 2007

The metabolic response on isologous transplantation of low numbers of isolated islets of langerhans in the rat. Diabetologia 12(4): 397, 1976

Transplantation of isolated islets of langerhans in diabetic dogs 2. the influence of histo compatibility. Journal of Surgical Research 27(3): 193-204, 1979

Transplantation of cryopreserved isolated adult human islets of langerhans into nude rats. Surgical Forum (Chicago) 37: 334-336, 1986