+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hematological parameters in preterm infants from birth to 16 weeks of age with reference to iron balance



Hematological parameters in preterm infants from birth to 16 weeks of age with reference to iron balance



Clinical Chemistry and Laboratory Medicine 46(4): 551-557



The objective of this study was to describe the natural kinetics of serum soluble transferrin receptor (S-TfR), ferritin and reticulocyte indices in preterm neonates, and to find out whether these analytes relate to hematocrit (Hct) level in determining the need for red cell (RBC) transfusions. During a 2-year period, 100 preterm neonates were recruited in a tertiary level neonatal intensive care unit. Inclusion criteria were gestational age < or =34 weeks or birth weight <2000 g. Biochemical markers of iron deficiency and hematological indices were serially analyzed from birth. This report focuses on the first 16 weeks after birth. The trends of the studied analytes were presented with reference ranges. RBC transfusions did not have a significant effect on reticulocyte hemoglobin content (CHr) or reticulocyte count. Reticulocytes were lowest after the first week and S-TfR at 9 weeks of age. CHr and fraction of immature reticulocytes were highest at birth and decreased thereafter. CHr and reticulocyte count were significantly different in two groups determined by Hct level (Hct < or > or =0.30). This difference was not observed in S-TfR or ferritin concentrations. In addition to reflecting the activity of erythropoiesis, S-TfR seems to reflect iron balance in preterm neonates. By using CHr and reticulocyte, it is possible to obtain more information about iron balance in relation to erythropoiesis, and it might be useful to combine this information with Hct before making a decision about a transfusion.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 031663088

Download citation: RISBibTeXText

PMID: 18605935

DOI: 10.1515/cclm.2008.109


Related references

Iron status at birth and at 4 weeks in preterm-SGA infants in comparison with preterm and term-AGA infants. Journal of Maternal-Fetal and Neonatal Medicine 25(8): 1474-1478, 2013

Doppler-derived parameters of diastolic left ventricular function in preterm infants with a birth weight <1500 g: Reference values and differences to term infants. Early Human Development 76(2): 101-114, 2004

Zinc, copper, manganese, and iron balance of parenterally fed very low birth weight preterm infants receiving a trace element supplement. Jpen. Journal of Parenteral and Enteral Nutrition 12(4): 382-386, 1988

Eye-hand co-ordination skills in very preterm infants <29 weeks gestation at 3 years: Effects of preterm birth and retinopathy of prematurity. Early Human Development 82(11): 739-745, 2006

A review of cord blood concentrations of iron status parameters to define reference ranges for preterm infants. Neonatology 104(3): 194-202, 2014

Serum biochemical and hematological parameters in crossbred swine from birth through eight weeks of age. Canadian Journal of Comparative Medicine 36(3): 202-209, 1972

Body composition at birth in preterm infants between 30 and 36 weeks gestation. Pediatric Obesity 10(1): 45-51, 2015

Placental pathology and neurological morbidity in preterm infants during the first two weeks after birth. Early Human Development 90(1): 21-25, 2014

Mortality in very preterm and very low birth weight infants according to place of birth and level of care: results of a national collaborative survey of preterm and very low birth weight infants in The Netherlands. Pediatrics 81(3): 404-411, 1988

Iron retention in preterm infants fed low iron intakes: a metabolic balance study. Early Human Development 86 Suppl 1: 49-53, 2010

Comparison of milk output between mothers of preterm and term infants: the first 6 weeks after birth. Journal of Human Lactation 21(1): 22-30, 2005

Heat loss from the skin of preterm and fullterm newborn infants during the first weeks after birth. Biology of the Neonate 50(1): 1-10, 1986

Risk factors associated with preterm (less than 37+0 weeks) and early preterm birth (less than 32+0 weeks): Univariate and multivariate analysis of 106 345 singleton births from the 1994 statewide perinatal survey of Bavaria. European Journal of Obstetrics and Gynecology and Reproductive Biology 80(2): 183-189, 1998

Risk factors associated with preterm (<37+0 weeks) and early preterm birth (<32+0 weeks): univariate and multivariate analysis of 106 345 singleton births from the 1994 statewide perinatal survey of Bavaria. European Journal of Obstetrics, Gynecology, and Reproductive Biology 80(2): 183-189, 1998

Iron Deficiency and Iron Homeostasis in Low Birth Weight Preterm Infants: A Systematic Review. Nutrients 11(5), 2019